(Q21986517)

Protein kinase-like domain superfamily

1 reference

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

1 reference

14 February 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

1 reference

14 February 2019

calcium-dependent protein serine/threonine kinase activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

1 reference

31 January 2018

calmodulin binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

1 reference

14 February 2019

protein serine/threonine kinase activity

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

protein binding

calmodulin-dependent protein kinase activity

IPI

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

mitogen-activated protein kinase binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

cell component

cytoplasm

5 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

31 January 2018

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

31 January 2018

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

nucleus

5 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

31 January 2018

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

31 January 2018

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

nucleus

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

cytoplasm

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

biological process

response to cytokine

3 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

1 reference

14 February 2019

regulation of tumor necrosis factor production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

ISO

14 February 2019

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

toll-like receptor signaling pathway

1 reference

31 January 2018

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

mRNA stabilization

1 reference

14 February 2019

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

response to lipopolysaccharide

vascular endothelial growth factor receptor signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

macropinocytosis

1 reference

14 February 2019

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

peptidyl-serine phosphorylation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

p38MAPK cascade

1 reference

14 February 2019

Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

protein autophosphorylation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

inner ear development

1 reference

14 February 2019

Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

cellular response to vascular endothelial growth factor stimulus

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

3'-UTR-mediated mRNA stabilization

ISS

ISO

inflammatory response

1 reference

31 January 2018

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49138&geneProductId=UniProtKB:P49138

regulation of interleukin-6 production

1 reference

14 February 2019

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

toll-like receptor signaling pathway

response to cytokine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

intracellular signal transduction

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49138

serine/threonine-protein kinase, active site

has part(s)

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference