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(Q21986656)
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English
Proviral integration site 2
mammalian protein found in Mus musculus
serine/threonine-protein kinase pim-2
Pim2
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q62070
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
Q62070
part of
Protein kinase-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62070
serine/threonine-protein kinase pim-1/2/3
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62070
Protein kinase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein kinase, ATP binding site, protein family
1 reference
based on heuristic
inferred from protein domain or family
Serine/threonine-protein kinase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q62070
encoded by
Pim2
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q62070
molecular function
transferase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
nucleotide binding
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
protein kinase activity
determination method
IDA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
Pim serine/threonine kinases regulate the stability of Socs-1 protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IDA
kinase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
protein serine/threonine kinase activity
determination method
IDA
IEA
ISO
6 references
retrieved
31 January 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62070&geneProductId=UniProtKB:Q62070
determination method
ISO
retrieved
31 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62070&geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
31 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62070&geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
31 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62070&geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
31 January 2018
stated in
Pim kinase-dependent inhibition of c-Myc degradation
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62070&geneProductId=UniProtKB:Q62070
determination method
IDA
retrieved
31 January 2018
stated in
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62070&geneProductId=UniProtKB:Q62070
determination method
IDA
protein binding
determination method
IPI
2 references
retrieved
14 February 2019
stated in
Pim kinase-dependent inhibition of c-Myc degradation
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IPI
retrieved
14 February 2019
stated in
Pim serine/threonine kinases regulate the stability of Socs-1 protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IPI
ATP binding
determination method
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
protein serine/threonine kinase activity
determination method
IBA
IDA
IEA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
Pim kinase-dependent inhibition of c-Myc degradation
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IDA
retrieved
14 February 2019
stated in
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IBA
cell component
cytoplasm
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IBA
biological process
positive regulation of autophagy
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IMP
phosphorylation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
negative regulation of protein binding
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IMP
positive regulation of transcription, DNA-templated
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Pim kinase-dependent inhibition of c-Myc degradation
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IMP
protein phosphorylation
determination method
IDA
IEA
ISO
4 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IDA
positive regulation of macroautophagy
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IMP
apoptotic mitochondrial changes
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IDA
regulation of mitotic cell cycle
determination method
IBA
1 reference
retrieved
31 January 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62070&geneProductId=UniProtKB:Q62070
determination method
IBA
positive regulation of I-kappaB kinase/NF-kappaB signaling
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IDA
protein autophosphorylation
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IBA
cell cycle
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
apoptotic process
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
negative regulation of cell population proliferation
determination method
IEA
ISO
ISS
3 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
response to virus
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
negative regulation of apoptotic process
determination method
IDA
IEA
IMP
ISO
5 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
ISO
retrieved
14 February 2019
stated in
PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IDA
protein stabilization
determination method
IDA
IEA
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
retrieved
14 February 2019
stated in
Pim kinase-dependent inhibition of c-Myc degradation
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IDA
G1/S transition of mitotic cell cycle
determination method
IEA
ISO
ISS
3 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q62070
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62070
determination method
IEA
has part(s)
serine/threonine-protein kinase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62070
protein kinase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62070
protein kinase, ATP binding site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q62070
Identifiers
RefSeq protein ID
NP_613072
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
18715
UniProt protein ID
Q62070
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q62070
Ensembl protein ID
ENSMUSP00000033495
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000033495
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