(Q21987038)

English

Tau tubulin kinase 2

mammalian protein found in Mus musculus

tau-tubulin kinase 2
protein bartleby
Ttbk2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q3UVR3

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

protein kinase activity

determination method

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

transferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

kinase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

determination method

2 references

protein serine/threonine kinase activity

determination method

6 references

16 September 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

16 September 2017

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

16 September 2017

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

16 September 2017

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

16 September 2017

Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

protein kinase activity

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

protein serine/threonine kinase activity

determination method

7 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

kinesin binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

determination method

1 reference

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

ciliary basal body

determination method

1 reference

16 September 2017

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

cell projection

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

determination method

2 references

ciliary transition zone

determination method

3 references

16 September 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

16 September 2017

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

16 September 2017

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

extracellular space

determination method

1 reference

16 September 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

intermediate filament cytoskeleton

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

ciliary transition zone

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

biological process

embryonic brain development

determination method

1 reference

14 February 2019

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

smoothened signaling pathway

determination method

1 reference

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

regulation of smoothened signaling pathway

determination method

1 reference

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

forebrain development

determination method

1 reference

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

protein phosphorylation

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

cell projection organization

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

embryonic digit morphogenesis

determination method

1 reference

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

neural tube development

determination method

1 reference

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

negative regulation of protein localization

determination method

1 reference

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

positive regulation of non-motile cilium assembly

determination method

1 reference

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

phosphorylation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

peptidyl-serine phosphorylation

determination method

3 references

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

16 September 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

16 September 2017

Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

regulation of cell shape

determination method

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UVR3&geneProductId=UniProtKB:Q3UVR3

determination method

microtubule cytoskeleton organization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

negative regulation of microtubule depolymerization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

peptidyl-serine phosphorylation

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

peptidyl-threonine phosphorylation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

cerebellum development

determination method

1 reference

14 February 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

cerebellar granular layer development

determination method

1 reference

14 February 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

cerebellar granule cell precursor tangential migration

determination method

1 reference

14 February 2019

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

regulation of cell migration

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

cilium assembly

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

negative regulation of protein localization to microtubule

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

negative regulation of microtubule binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UVR3

determination method

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q3UVR3

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q3UVR3

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000055032

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000055032

ENSMUSP00000083001

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000083001

ENSMUSP00000028740

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000028740

ENSMUSP00000118905

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000118905

ENSMUSP00000121996

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121996

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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