(Q21987727)

English

Metallothionein 3

mammalian protein found in Mus musculus

metallothionein-3
metallothionein-III
Mt3
GIF
growth inhibitory factor
MT-III

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Metallothionein domain superfamily, vertebrate

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28184

Metallothionein, vertebrate

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28184

Metallothionein domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28184

Metallothionein, vertebrate, metal binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

metal ion binding

determination method

3 references

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28184&geneProductId=UniProtKB:P28184

determination method

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28184&geneProductId=UniProtKB:P28184

determination method

5 June 2018

Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28184&geneProductId=UniProtKB:P28184

determination method

copper ion binding

determination method

2 references

cadmium ion binding

determination method

2 references

zinc ion binding

determination method

3 references

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

metal ion binding

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

astrocyte end-foot

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

determination method

1 reference

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28184&geneProductId=UniProtKB:P28184

determination method

determination method

2 references

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28184&geneProductId=UniProtKB:P28184

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

postsynaptic density

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

dendritic spine

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

rough endoplasmic reticulum

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

mitochondrial outer membrane

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

astrocyte projection

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

plasma membrane

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

extracellular space

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

biological process

protein kinase B signaling

determination method

2 references

response to hypoxia

determination method

2 references

regulation of response to food

determination method

1 reference

14 February 2019

Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

histone modification

determination method

2 references

leptin-mediated signaling pathway

determination method

1 reference

14 February 2019

Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

astrocyte development

determination method

1 reference

14 February 2019

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

zinc ion transport

determination method

1 reference

14 February 2019

Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

zinc ion homeostasis

determination method

2 references

cellular lipid catabolic process

determination method

1 reference

14 February 2019

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

brain development

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

positive regulation of lysosomal membrane permeability

determination method

1 reference

14 February 2019

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

cholesterol catabolic process

determination method

1 reference

14 February 2019

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

positive regulation of oxygen metabolic process

determination method

1 reference

14 February 2019

Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

response to oxidative stress

determination method

1 reference

14 February 2019

Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

regulation of protein glycosylation

determination method

1 reference

14 February 2019

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

protein stabilization

determination method

2 references

negative regulation of neuron apoptotic process

determination method

1 reference

14 February 2019

Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

negative regulation of neuron death

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

negative regulation of neurogenesis

determination method

1 reference

14 February 2019

Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

negative regulation of autophagy

determination method

1 reference

14 February 2019

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

cellular response to hypoxia

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

negative regulation of hydrogen peroxide catabolic process

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

cellular zinc ion homeostasis

determination method

3 references

5 June 2018

Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28184&geneProductId=UniProtKB:P28184

determination method

5 June 2018

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28184&geneProductId=UniProtKB:P28184

determination method

5 June 2018

Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28184&geneProductId=UniProtKB:P28184

determination method

positive regulation of catalytic activity

determination method

1 reference

14 February 2019

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

ERK1 and ERK2 cascade

determination method

2 references

negative regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

energy reserve metabolic process

determination method

1 reference

14 February 2019

Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

cellular metal ion homeostasis

determination method

1 reference

14 February 2019

Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

apoptotic process

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

cellular zinc ion homeostasis

determination method

4 references

14 February 2019

Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

detoxification of copper ion

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

3 references

14 February 2019

Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

cellular response to cadmium ion

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

cellular response to copper ion

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

cellular response to zinc ion

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28184

determination method

Metallothionein, vertebrate, metal binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28184

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000034211

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000034211

ENSMUSP00000148345

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000148345

ENSMUSP00000148383

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000148383

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21987727&oldid=2023400780"