(Q21987932)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QX98

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

sequence-specific DNA binding

1 reference

14 February 2019

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

1 reference

14 February 2019

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

24 April 2018

Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QX98&geneProductId=UniProtKB:Q9QX98

14 February 2019

Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

chromatin binding

2 references

E-box binding

1 reference

14 February 2019

RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

protein binding

IPI

1 reference

14 February 2019

p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

IPI

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

The DNA-binding activity of transcription factor PTF1 parallels the synthesis of pancreas-specific mRNAs during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

1 reference

14 February 2019

intracellular anatomical structure

TAS

1 reference

24 April 2018

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QX98&geneProductId=UniProtKB:Q9QX98

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

1 reference

14 February 2019

TAS

nucleus

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

The DNA-binding activity of transcription factor PTF1 parallels the synthesis of pancreas-specific mRNAs during mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

transcription regulator complex

IC

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

cytoplasm

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

biological process

cell fate commitment

retina layer formation

1 reference

14 February 2019

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

hindbrain development

1 reference

14 February 2019

p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QX98&geneProductId=UniProtKB:Q9QX98

1 reference

24 April 2018

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

1 reference

14 February 2019

cerebellum development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

ISO

14 February 2019

Mutations in PTF1A cause pancreatic and cerebellar agenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

generation of neurons

Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

1 reference

14 February 2019

positive regulation of transcription, DNA-templated

regulation of neural retina development

1 reference

14 February 2019

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

retina morphogenesis in camera-type eye

1 reference

14 February 2019

Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

retinoic acid receptor signaling pathway

1 reference

14 February 2019

p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

tissue development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

ISO

14 February 2019

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

neuron fate commitment

1 reference

14 February 2019

Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

amacrine cell differentiation

1 reference

14 February 2019

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

positive regulation of transcription by RNA polymerase II

Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

endocrine pancreas development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

1 reference

14 February 2019

transcription by RNA polymerase II

TAS

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QX98&geneProductId=UniProtKB:Q9QX98

regulation of transcription, DNA-templated

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

ISO

14 February 2019

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

14 February 2019

Mutations in PTF1A cause pancreatic and cerebellar agenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QX98

exocrine pancreas development

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

InterPro Release 71.0