(Q21988598)

http://www.ebi.ac.uk/interpro/protein/Q9WUN2

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

protein kinase activity

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

10 references

9 May 2019

NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

Activation of STAT6 by STING is critical for antiviral innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

1 reference

9 May 2019

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

protein serine/threonine kinase activity

IDA

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

identical protein binding

IDA

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

protein serine/threonine kinase activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

protein phosphatase binding

IBA

1 reference

9 May 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

immune system process

1 reference

9 May 2019

positive regulation of xenophagy

1 reference

9 May 2019

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

negative regulation of gene expression

1 reference

9 May 2019

Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

defense response to virus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

peptidyl-serine phosphorylation

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

27 March 2018

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUN2&geneProductId=UniProtKB:Q9WUN2

activation of innate immune response

IDA

1 reference

9 May 2019

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

innate immune response

1 reference

14 February 2019

dendritic cell proliferation

1 reference

9 May 2019

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

defense response to Gram-positive bacterium

IGI

1 reference

9 May 2019

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

protein phosphorylation

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

regulation of gene expression

1 reference

9 May 2019

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

peptidyl-serine phosphorylation

IGI

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

14 February 2019

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

regulation of cellular metabolic process

IBA

1 reference

9 May 2019

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

positive regulation of type I interferon-mediated signaling pathway

IGI

1 reference

9 May 2019

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

peptidyl-serine phosphorylation

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

peptidyl-threonine phosphorylation

IBA

innate immune response

regulation of type I interferon production

ISS

innate immune response

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUN2

has part(s)

protein kinase domain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9WUN2

protein kinase, ATP binding site

1 reference

stated in

InterPro Release 71.0