(Q21988768)

English

Netrin 1

mammalian protein found in Mus musculus

Ntn1
netrin-1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Tissue inhibitor of metalloproteinases-like, OB-fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09118

Galactose-binding-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O09118

Laminin EGF domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Laminin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Netrin module, non-TIMP type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Netrin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method

4 references

9 May 2019

Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

extracellular matrix structural constituent

determination method

1 reference

1 January 2018

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O09118&geneProductId=UniProtKB:O09118

determination method

extracellular matrix structural constituent

determination method

extracellular matrix structural constituent

determination method

1 reference

9 May 2019

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

determination method

1 reference

9 May 2019

Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

basement membrane

determination method

1 reference

14 February 2019

Transcriptome-based systematic identification of extracellular matrix proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

determination method

1 reference

9 May 2019

Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

extracellular matrix

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

collagen-containing extracellular matrix

determination method

1 reference

9 May 2019

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

biological process

determination method

1 reference

9 May 2019

Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

mammary gland development

determination method

1 reference

9 May 2019

Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

mammary gland duct morphogenesis

determination method

1 reference

9 May 2019

Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

inner ear morphogenesis

determination method

1 reference

9 May 2019

Analysis of Netrin 1 receptors during inner ear development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

positive regulation of cell population proliferation

determination method

1 reference

9 May 2019

Netrin-1 is required for the normal development of spinal cord oligodendrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

negative regulation of axon extension

determination method

1 reference

9 May 2019

Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

anterior/posterior axon guidance

determination method

1 reference

9 May 2019

Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

apoptotic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

nuclear migration

determination method

1 reference

9 May 2019

Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

cell-cell adhesion

determination method

1 reference

9 May 2019

Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

determination method

6 references

9 May 2019

Netrin-1 is required for the normal development of spinal cord oligodendrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

Diffusion tensor magnetic resonance imaging and tract-tracing analysis of Probst bundle structure in Netrin1- and DCC-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

Boc is a receptor for sonic hedgehog in the guidance of commissural axons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

regulation of synapse assembly

determination method

3 references

9 May 2019

Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

9 May 2019

Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

chemorepulsion of axon

determination method

1 reference

9 May 2019

Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

motor neuron axon guidance

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

animal organ morphogenesis

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

tissue development

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

dendrite development

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O09118

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000021284

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000021284

ENSMUSP00000104314

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000104314

ENSMUSP00000121193

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121193

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

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