(Q21989148)

Frizzled cysteine-rich domain superfamily

1 reference

Tissue inhibitor of metalloproteinases-like, OB-fold

1 reference

Frizzled domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Netrin module, non-TIMP type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Netrin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

receptor ligand activity

1 reference

14 February 2019

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

endopeptidase activator activity

1 reference

14 February 2019

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

1 reference

24 April 2018

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

4 references

14 February 2019

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

enzyme activator activity

IPI

1 reference

14 February 2019

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

G protein-coupled receptor activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

Wnt-activated receptor activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

2 references

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

SARPs: a family of secreted apoptosis-related proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

integral component of membrane

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

SARPs: a family of secreted apoptosis-related proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

cellular response to extracellular stimulus

biological process

1 reference

14 February 2019

Screen for genes regulated during early kidney morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

1 reference

14 February 2019

Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

positive regulation of endopeptidase activity

1 reference

14 February 2019

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

regulation of apoptotic process

1 reference

14 February 2019

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

Wnt signaling pathway involved in somitogenesis

1 reference

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

14 February 2019

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

Sfrp1 and Sfrp2 are required for normal male sexual development in mice

male gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

regulation of establishment of planar polarity

1 reference

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

regulation of neuron projection development

1 reference

14 February 2019

SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

collagen fibril organization

1 reference

14 February 2019

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

convergent extension involved in axis elongation

1 reference

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

development of primary male sexual characteristics

1 reference

14 February 2019

Sfrp1 and Sfrp2 are required for normal male sexual development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of mesodermal cell fate specification

1 reference

14 February 2019

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

cellular response to X-ray

1 reference

14 February 2019

Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of Wnt signaling pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

1 reference

14 February 2019

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

hematopoietic stem cell proliferation

1 reference

14 February 2019

Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

chondrocyte development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

embryonic digit morphogenesis

1 reference

14 February 2019

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

Wnt signaling pathway

1 reference

14 February 2019

negative regulation of gene expression

1 reference

14 February 2019

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm

sclerotome development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

positive regulation of peptidyl-serine phosphorylation

IEP

1 reference

14 February 2019

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

positive regulation of angiogenesis

1 reference

14 February 2019

Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

planar cell polarity pathway involved in neural tube closure

1 reference

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of BMP signaling pathway

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of cardiac muscle cell apoptotic process

1 reference

14 February 2019

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

regulation of Wnt signaling pathway

1 reference

14 February 2019

SARPs: a family of secreted apoptosis-related proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

1 reference

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

positive regulation of cell growth

1 reference

14 February 2019

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of cell migration

1 reference

14 February 2019

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

positive regulation of osteoblast differentiation

1 reference

14 February 2019

Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

cartilage development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

regulation of cell population proliferation

1 reference

14 February 2019

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

14 February 2019

SARPs: a family of secreted apoptosis-related proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

regulation of stem cell division

1 reference

14 February 2019

Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

neural tube development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

positive regulation of cell population proliferation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

branching involved in blood vessel morphogenesis

1 reference

14 February 2019

Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

post-anal tail morphogenesis

1 reference

14 February 2019

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of dermatome development

1 reference

14 February 2019

SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of planar cell polarity pathway involved in axis elongation

1 reference

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of JUN kinase activity

1 reference

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of canonical Wnt signaling pathway

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

24 April 2018

Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

anterior/posterior pattern specification

1 reference

14 February 2019

Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

digestive tract morphogenesis

1 reference

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

1 reference

14 February 2019

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

regulation of midbrain dopaminergic neuron differentiation

1 reference

14 February 2019

SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

G protein-coupled receptor signaling pathway

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97299&geneProductId=UniProtKB:P97299

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

positive regulation of canonical Wnt signaling pathway

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

non-canonical Wnt signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

canonical Wnt signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

negative regulation of canonical Wnt signaling pathway

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97299

1 reference

frizzled domain

1 reference

Netrin module, non-TIMP type

1 reference