(Q21989156)

Frizzled cysteine-rich domain superfamily

1 reference

Secreted frizzled-related protein 1

1 reference

Frizzled domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Netrin module, non-TIMP type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Netrin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

1 reference

14 February 2019

Myocilin is a modulator of Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

G protein-coupled receptor activity

IPI

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

3 references

14 February 2019

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

Wnt-activated receptor activity

IBA

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

1 reference

14 February 2019

Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

31 January 2018

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

integral component of membrane

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

1 reference

14 February 2019

Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

Spatial gene expression in the T-stage mouse metanephros

ureteric bud development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

regulation of neuron projection development

IEP

1 reference

14 February 2019

SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of Wnt signaling pathway

3 references

convergent extension involved in somitogenesis

1 reference

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of osteoblast differentiation

1 reference

14 February 2019

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of ossification

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

1 reference

14 February 2019

Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

positive regulation of extrinsic apoptotic signaling pathway

1 reference

14 February 2019

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

substrate adhesion-dependent cell spreading

1 reference

14 February 2019

Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of canonical Wnt signaling pathway

ISO

7 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

31 January 2018

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

31 January 2018

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

31 January 2018

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

31 January 2018

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

31 January 2018

The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

cellular response to hypoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

cellular response to transforming growth factor beta stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

dopaminergic neuron differentiation

1 reference

14 February 2019

Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

cellular response to vitamin D

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of gene expression

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

Sfrp1 and Sfrp2 are required for normal male sexual development in mice

female gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

cellular response to estrogen stimulus

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

cellular response to prostaglandin E stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

neural tube development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

digestive tract morphogenesis

1 reference

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

Wnt signaling pathway involved in somitogenesis

1 reference

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

regulation of branching involved in prostate gland morphogenesis

1 reference

14 February 2019

Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

Sfrp1 and Sfrp2 are required for normal male sexual development in mice

male gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

cellular response to X-ray

1 reference

14 February 2019

Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

stromal-epithelial cell signaling involved in prostate gland development

1 reference

14 February 2019

Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

Wnt signaling pathway, planar cell polarity pathway

IEP

1 reference

14 February 2019

Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

osteoblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of B cell differentiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

cellular response to interleukin-1

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of osteoblast proliferation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of planar cell polarity pathway involved in axis elongation

1 reference

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

actin cytoskeleton organization

1 reference

14 February 2019

Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

regulation of establishment of planar polarity

ISO

1 reference

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

somatic stem cell population maintenance

1 reference

14 February 2019

Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

development of primary male sexual characteristics

1 reference

14 February 2019

Sfrp1 and Sfrp2 are required for normal male sexual development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

cellular response to starvation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

cellular response to estradiol stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

cellular response to BMP stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

bone trabecula formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

Wnt signaling pathway

1 reference

14 February 2019

neural crest cell fate commitment

1 reference

14 February 2019

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

planar cell polarity pathway involved in neural tube closure

1 reference

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of BMP signaling pathway

1 reference

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

1 reference

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of JUN kinase activity

1 reference

14 February 2019

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

anterior/posterior pattern specification

1 reference

14 February 2019

Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

negative regulation of osteoclast differentiation

1 reference

31 January 2018

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

regulation of midbrain dopaminergic neuron differentiation

1 reference

14 February 2019

SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

G protein-coupled receptor signaling pathway

1 reference

31 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C4U3&geneProductId=UniProtKB:Q8C4U3

regulation of ossification

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

non-canonical Wnt signaling pathway

ISO

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

canonical Wnt signaling pathway

IBA

3 references

negative regulation of canonical Wnt signaling pathway

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C4U3

1 reference

frizzled domain

1 reference

Netrin module, non-TIMP type

1 reference