(Q21989671)

English

Topoisomerase (DNA) I

mammalian protein found in Mus musculus

DNA topoisomerase I
DNA topoisomerase 1
Top1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

DNA topoisomerase I, DNA binding, N-terminal domain 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA topoisomerase I, subgroup

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA topoisomerase I, catalytic core, alpha/beta subdomain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA breaking-rejoining enzyme, catalytic core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA topoisomerase I, DNA binding, N-terminal domain 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA topoisomerase I domain, eukaryotic-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA topoisomerase I, DNA binding, eukaryotic-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Topoisomerase I C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA topoisomerase I, catalytic core, eukaryotic-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA topoisomerase I, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

DNA topoisomerase type I (single strand cut, ATP-independent) activity

determination method

7 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

DNA topoisomerase I in the mouse central nervous system: Age and sex dependence

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

Analysis of expression and function of topoisomerase I and II during meiosis in male mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

Modulation of topoisomerase activities by tumor necrosis factor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

chromatin binding

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

isomerase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

DNA topoisomerase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

core promoter sequence-specific DNA binding

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

chromatin DNA binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

protein-containing complex binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

core promoter sequence-specific DNA binding

determination method

1 reference

5 June 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

3 references

DNA topoisomerase type I (single strand cut, ATP-independent) activity

determination method

8 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

DNA topoisomerase I in the mouse central nervous system: Age and sex dependence

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Analysis of expression and function of topoisomerase I and II during meiosis in male mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Modulation of topoisomerase activities by tumor necrosis factor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

determination method

1 reference

14 February 2019

DNA topoisomerase I in the mouse central nervous system: Age and sex dependence

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

determination method

1 reference

14 February 2019

DNA topoisomerase I in the mouse central nervous system: Age and sex dependence

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

replication fork protection complex

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

determination method

3 references

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

DNA topoisomerase I in the mouse central nervous system: Age and sex dependence

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Analysis of expression and function of topoisomerase I and II during meiosis in male mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

fibrillar center

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

dense fibrillar component

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

biological process

chromatin remodeling

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

embryonic cleavage

determination method

1 reference

14 February 2019

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

rhythmic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

chromosome segregation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

circadian regulation of gene expression

determination method

3 references

DNA replication

determination method

1 reference

16 July 2018

Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

circadian rhythm

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

DNA topological change

determination method

5 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

DNA topoisomerase I in the mouse central nervous system: Age and sex dependence

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

16 July 2018

Modulation of topoisomerase activities by tumor necrosis factor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04750&geneProductId=UniProtKB:Q04750

determination method

rRNA transcription

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

DNA topological change

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

DNA topoisomerase I in the mouse central nervous system: Age and sex dependence

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Modulation of topoisomerase activities by tumor necrosis factor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04750

determination method

DNA topoisomerase I domain, eukaryotic-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA topoisomerase I, catalytic core, eukaryotic-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA topoisomerase I, DNA binding, eukaryotic-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

DNA topoisomerase I, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

Topoisomerase I C-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04750

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000105094

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000105094

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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