(Q21990199)

English

Sulfatase 2

mammalian protein found in Mus musculus

extracellular sulfatase Sulf-2
Sulf2

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Extracellular sulfatase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CFG0

Alkaline-phosphatase-like, core domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CFG0

Sulfatase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Extracellular sulfatase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

arylsulfatase activity

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

catalytic activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

sulfuric ester hydrolase activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

N-acetylglucosamine-6-sulfatase activity

determination method

3 references

27 March 2018

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

glycosaminoglycan binding

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

N-acetylglucosamine-6-sulfatase activity

determination method

4 references

9 May 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

plasma membrane

determination method

1 reference

27 March 2018

WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

determination method

5 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

endoplasmic reticulum

determination method

4 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

extracellular space

determination method

1 reference

9 May 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

endoplasmic reticulum

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

determination method

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

biological process

glomerular basement membrane development

determination method

1 reference

27 March 2018

WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

kidney development

determination method

1 reference

9 May 2019

Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

positive regulation of canonical Wnt signaling pathway

determination method

1 reference

9 May 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

chondrocyte development

determination method

1 reference

9 May 2019

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

embryonic skeletal system development

determination method

1 reference

9 May 2019

Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

negative regulation of fibroblast growth factor receptor signaling pathway

determination method

liver regeneration

determination method

1 reference

9 May 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

cartilage development

determination method

1 reference

9 May 2019

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

glomerular filtration

determination method

1 reference

9 May 2019

WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

response to wounding

determination method

1 reference

9 May 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

regulation of hepatocyte proliferation

determination method

1 reference

9 May 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

sulfur compound metabolic process

determination method

1 reference

9 May 2019

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

glial cell-derived neurotrophic factor receptor signaling pathway

determination method

1 reference

9 May 2019

SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

positive regulation of vascular endothelial growth factor production

determination method

1 reference

27 March 2018

WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

esophagus smooth muscle contraction

determination method

1 reference

9 May 2019

SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

determination method

1 reference

9 May 2019

SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

bone development

determination method

1 reference

9 May 2019

Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

heparan sulfate proteoglycan metabolic process

determination method

3 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CFG0&geneProductId=UniProtKB:Q8CFG0

determination method

heparan sulfate proteoglycan metabolic process

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

glial cell-derived neurotrophic factor receptor signaling pathway

determination method

negative regulation of fibroblast growth factor receptor signaling pathway

determination method

3 references

9 May 2019

WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CFG0

determination method

positive regulation of canonical Wnt signaling pathway

determination method

regulation of hepatocyte proliferation

determination method

positive regulation of Wnt signaling pathway

determination method

Sulfatase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CFG0

Extracellular sulfatase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CFG0

Sulfatase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CFG0

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000085405

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000085405

ENSMUSP00000104872

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000104872

ENSMUSP00000154315

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000154315

ENSMUSP00000154557

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000154557

ENSMUSP00000154724

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000154724

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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