(Q21991683)

http://www.ebi.ac.uk/interpro/protein/O54928

Suppressor of cytokine signalling 5

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54928

SH2 domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54928

SOCS5, SOCS box domain, protein family

1 reference

SH2 domain, protein family

1 reference

SOCS4/SOCS5 domain, protein family

1 reference

SOCS box domain, protein family

1 reference

epidermal growth factor receptor binding

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

protein kinase inhibitor activity

IPI

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54928&geneProductId=UniProtKB:O54928

1 reference

14 February 2019

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

kinase inhibitor activity

IPI

1 reference

14 February 2019

Twenty proteins containing a C-terminal SOCS box form five structural classes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

1-phosphatidylinositol-3-kinase regulator activity

NAS

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

1 reference

14 February 2019

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

phosphatidylinositol 3-kinase complex

NAS

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

positive regulation of T-helper 1 cell differentiation

biological process

1 reference

14 February 2019

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

negative regulation of epidermal growth factor-activated receptor activity

IDA

3 references

negative regulation of T-helper 2 cell differentiation

1 reference

14 February 2019

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

1 reference

27 March 2018

Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54928&geneProductId=UniProtKB:O54928

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

intracellular signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

negative regulation of epidermal growth factor receptor signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54928&geneProductId=UniProtKB:O54928

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

ISO

3 references

protein ubiquitination

1 reference

14 February 2019

negative regulation of protein kinase activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54928&geneProductId=UniProtKB:O54928

cytokine-mediated signaling pathway

1 reference

14 February 2019

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

negative regulation of receptor signaling pathway via JAK-STAT

IDA

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54928&geneProductId=UniProtKB:O54928

cellular response to low-density lipoprotein particle stimulus

1 reference

14 February 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

vascular endothelial cell response to fluid shear stress

1 reference

14 February 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

negative regulation of endothelial cell activation

1 reference

14 February 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

negative regulation of interleukin-6 production

IC

1 reference

14 February 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

negative regulation of inflammatory response

1 reference

14 February 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

negative regulation of monocyte chemotactic protein-1 production

1 reference

14 February 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

regulation of phosphatidylinositol 3-kinase activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928

phosphatidylinositol phosphate biosynthetic process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54928