(Q22010219)

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A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity

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scholarly article

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A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity (English)

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NAD(P)H quinone dehydrogenase 1

1 reference

GOA release 2020-03-11

response to toxic substance

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

J L Moran

1

author given names

J L

author last names

Moran

1 reference

6 February 2023

D Siegel

2

author given names

D

author last names

Siegel

1 reference

6 February 2023

D Ross

3

author given names

D

author last names

Ross

1 reference

6 February 2023

language of work or name

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publication date

6 July 1999

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Proceedings of the National Academy of Sciences of the United States of America

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96

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8150-5

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14

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Protein measurement with the Folin phenol reagent

1 reference

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19 March 2017

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Analysis of target cell susceptibility as a basis for the development of a chemoprotective strategy against benzene-induced hematotoxicities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

The toxicity of benzene and its metabolism and molecular pathology in human risk assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

19 March 2017

In vitro effects of benzene metabolites on mouse bone marrow stromal cells

1 reference

https://api.crossref.org/works/10.1073/PNAS.96.14.8150

22 April 2017

Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Environmental exposure to benzene: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Induction of apoptosis by benzene metabolites in HL60 and CD34+ human bone marrow progenitor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Transcriptional regulation of the human NAD(P)H:quinone oxidoreductase (NQO1) gene by monofunctional inducers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Chemical and molecular regulation of enzymes that detoxify carcinogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Acute nonlymphocytic leukemia: expression in cells restricted to granulocytic and monocytic differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

12 September 2017

Antioxidant response element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

27 September 2017

Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

27 September 2017

Human NAD(P)H:quinone oxidoreductase induction in human hepatoma cells after exposure to industrial acrylates, phenolics, and metals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

27 September 2017

Ionizing radiation effects on the KG1a primitive hematopoietic cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

27 September 2017

Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity: evidence for a NAD(P)H:quinone reductase-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

27 September 2017

Characterization of quinone reductase, glutathione and glutathione S-transferase in human myeloid cell lines: induction by 1,2-dithiole-3-thione and effects on hydroquinone-induced cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

27 September 2017

Antioxidants and AP-1 activation: a brief overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Oxidative DNA damage and apoptosis induced by benzene metabolites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells, mouse bone marrow macrophages and human bone marrow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Differences in xenobiotic detoxifying activities between bone marrow stromal cells from mice and rats: implications for benzene-induced hematotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Phorbol ester effect on differentiation of human myeloid leukemia cell lines blocked at different stages of maturation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Quinones as toxic metabolites of benzene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Modulation of stromal cell function in DBA/2J and B6C3F1 mice exposed to benzene or phenol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Reductive addition of glutathione to p-benzoquinone, 2-hydroxy-p-benzoquinone, and p-benzoquinone epoxides. Effect of the hydroxy- and glutathionyl substituents on p-benzohydroquinone autoxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Induction of quinone reductase and glutathione in bone marrow cells by 1,2-dithiole-3-thione: effect on hydroquinone-induced cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

30 May 2018

Benzene metabolism by human liver microsomes in relation to cytochrome P450 2E1 activity.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.14.8150

21 January 2018

A proposed mechanism of benzene toxicity: formation of reactive intermediates from polyphenol metabolites.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.14.8150

21 January 2018

Redox regulation of fos and jun DNA-binding activity in vitro

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.96.14.8150

21 January 2018

Characterization and phenotypic analysis of differentiating CD34+ human bone marrow cells in liquid culture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

29 November 2018

DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22203

29 November 2018

Metabolism and cytotoxicity of trans,trans-muconaldehyde and its derivatives: potential markers of benzene ring cleavage reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloperoxidase expression in CD34+ normal human hematopoietic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxidase activity in murine and human hematopoietic progenitor cells: potential relevance to benzene-induced toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of 1,2,4-benzenetriol-generated active oxygen species and induction of phase II enzymes by green tea polyphenols

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathionyl hydroquinone: a potent pro-oxidant and a possible toxic metabolite of benzene

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Report on the workshop entitled: "Modeling chemically induced leukemia--implications for benzene risk assessment"

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of quinol thioethers in bone marrow of hydroquinone/phenol-treated rats and mice and their potential role in benzene-mediated hematotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of benzene inhalation on murine pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PMA inhibits the growth of human fibroblasts after the induction of immediate-early genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzene disposition in the rat after exposure by inhalation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute and chronic dose/response effects of inhaled benzene on multipotential hematopoietic stem (CFU-S) and granulocyte/macrophage progenitor (GM-CFU-C) cells in CD-1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro assessment of marrow ‘stem cell’and stromal cell function in aplastic anaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of trans,trans-muconaldehyde by aldehyde and alcohol dehydrogenases: identification of a novel metabolite

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10393963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.96.14.8150

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1999PNAS...96.8150M

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