(Q22010813)

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The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

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scholarly article

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The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity (English)

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Furin, paired basic amino acid cleaving enzyme

1 reference

GOA release 2020-03-11

negative regulation of nerve growth factor production

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GOA release 2020-03-11

author name string

M Zhong

1

author given names

M

author last names

Zhong

1 reference

7 February 2023

J S Munzer

2

author given names

J S

author last names

Munzer

1 reference

7 February 2023

A Basak

3

author given names

A

author last names

Basak

1 reference

7 February 2023

S Benjannet

4

author given names

S

author last names

Benjannet

1 reference

7 February 2023

S J Mowla

5

author given names

S J

author last names

Mowla

1 reference

7 February 2023

E Decroly

6

author given names

E

author last names

Decroly

1 reference

7 February 2023

M Chrétien

7

author given names

M

author last names

Chrétien

1 reference

7 February 2023

N G Seidah

8

author given names

N G

author last names

Seidah

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7 February 2023

language of work or name

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publication date

26 November 1999

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Journal of Biological Chemistry

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274

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33913-20

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48

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Inhibition of processing of parathyroid hormone-related peptide by anti-sense furin: effect in vitro and in vivo on rat Leydig (H-500) tumor cells

1 reference

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A novel peptide designated PYLa and its precursor as predicted from cloned mRNA of Xenopus laevis skin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Subtilases: the superfamily of subtilisin-like serine proteases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

1 reference

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7 January 2021

based on heuristic

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Folding pathway mediated by an intramolecular chaperone: characterization of the structural changes in pro-subtilisin E coincident with autoprocessing

1 reference

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7 January 2021

based on heuristic

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Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells

1 reference

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7 January 2021

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A novel Kex2 enzyme can process the proregion of the yeast alpha-factor leader in the endoplasmic reticulum instead of in the Golgi

1 reference

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7 January 2021

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Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

1 reference

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7 January 2021

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Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: comparison with PC5, furin and PC7, implication in pro-BDNF processing.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Eukaryotic protein processing: endoproteolysis of precursor proteins

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The proprotein convertases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Catalysis of a protein folding reaction: thermodynamic and kinetic analysis of subtilisin BPN' interactions with its propeptide fragment.

1 reference

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7 January 2021

based on heuristic

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Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family

1 reference

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7 January 2021

based on heuristic

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Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of pH on the affinities of enzymes for substrates and inhibitors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered alpha 2-macroglobulin containing a furin recognition sequence in the bait region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Secretion and autoproteolytic maturation of subtilisin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

1 reference

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7 January 2021

based on heuristic

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Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Processing of the Ebola virus glycoprotein by the proprotein convertase furin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural elements that direct specific processing of different mammalian subtilisin-like prohormone convertases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro characterization of the novel proprotein convertase PC7.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of soluble recombinant furin by human proteinase inhibitor 8

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

The Pore-forming Toxin Proaerolysin Is Activated by Furin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

New vaccinia virus recombination plasmids incorporating a synthetic late promoter for high level expression of foreign proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Determinants for protein translocation across mammalian endoplasmic reticulum. Membrane insertion of truncated and full-length prelysozyme molecules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the kexin from Schizosaccharomyces pombe requires internal cleavage of its initially cleaved prosequence

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.274.48.33913

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