(Q22241666)

PubMed

PubMed publication ID

17122358

8 February 2023

Stephen O’Rahilly

series ordinal

2

author given names

Stephen

author last names

O'Rahilly

1 reference

PubMed

PubMed publication ID

17122358

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

8 February 2023

language of work or name

English

0 references

publication date

December 2006

0 references

published in

Endocrine Reviews

0 references

volume

27

0 references

issue

7

0 references

page(s)

710-718

0 references

cites work

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Prevalence and trends in overweight among US children and adolescents, 1999-2000

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Lean body mass in twins

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A role for beta-melanocyte-stimulating hormone in human body-weight regulation

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Obesity, diabetes and functions for proopiomelanocortin-derived peptides

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Genetic and environmental contributions to the association between body height and educational attainment: a study of adult Finnish twins

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Genetic and environmental factors in relative body weight and human adiposity

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A frameshift mutation in MC4R associated with dominantly inherited human obesity

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A frameshift mutation in human MC4R is associated with a dominant form of obesity

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Obesity as a medical problem

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Genetics of body-weight regulation

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Partial leptin deficiency and human adiposity.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

The severely obese patient--a genetic work-up

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A leptin missense mutation associated with hypogonadism and morbid obesity.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

The emerging pattern of the genetic contribution to human obesity

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

The Body-Mass Index of Twins Who Have Been Reared Apart

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A cross-sectional examination of height, weight, and body mass index in adult twins

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Rapid rewiring of arcuate nucleus feeding circuits by leptin.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Trophic action of leptin on hypothalamic neurons that regulate feeding

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Genetics of Hair and Skin Color

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Monogenic obesity in humans

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Prevalence of Mutations and Functional Analyses of Melanocortin 4 Receptor Variants Identified among 750 Men with Juvenile-Onset Obesity

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Heterozygosity for aPOMC-Null Mutation and Increased Obesity Risk in Humans

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Circulating leptin in normal children and during the dynamic phase of juvenile obesity: relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study.

1 reference

https://api.crossref.org/works/10.1210%2FER.2006-0040

7 January 2021

Identifiers

DOI

10.1210/ER.2006-0040

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

17122358

1 reference

Consolidated OpenCitations Corpus – April 2017