(Q22251042)

Dimensions Publication ID

Dimensions

1053003644

Nature Reviews Drug Discovery

7 February 2023

language of work or name

English

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publication date

20 January 2006

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published in

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volume

5

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page(s)

160-170

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issue

2

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cites work

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

Calcium, free radicals and excitotoxins in neuronal apoptosis.

31 March 2020

1 reference

Glutamate neurotoxicity and diseases of the nervous system

31 March 2020

1 reference

Excitatory amino acid neurotoxicity and neurodegenerative disease

31 March 2020

1 reference

Evidence that the loss of the voltage-dependent Mg2+ block at the N-methyl-D-aspartate receptor underlies receptor activation during inhibition of neuronal metabolism

31 March 2020

1 reference

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

31 March 2020

1 reference

NMDA receptor pathways as drug targets

31 March 2020

1 reference

Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. GAIN International Investigators

31 March 2020

1 reference

Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial

31 March 2020

1 reference

Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide

31 March 2020

1 reference

Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

31 March 2020

1 reference

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

31 March 2020

1 reference

Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation.

31 March 2020

1 reference

Memantine in moderate-to-severe Alzheimer's disease

31 March 2020

1 reference

Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300).

31 March 2020

1 reference

The toxic effect of sodium L-glutamate on the inner layers of the retina.

31 March 2020

1 reference

Glutaate-induced retinal degeneration in neonatal mice. Electron microscopy of the acutely evolving lesion

31 March 2020

1 reference

Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine

31 March 2020

1 reference

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

31 March 2020

1 reference

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

31 March 2020

1 reference

Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death

31 March 2020

1 reference

New perspectives on glaucoma

31 March 2020

1 reference

Saving the nerve from glaucoma: memantine to caspaces

31 March 2020

1 reference

Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis

31 March 2020

1 reference

Caspase cascades in human immunodeficiency virus-associated neurodegeneration.

31 March 2020

1 reference

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

31 March 2020

1 reference

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures.

31 March 2020

1 reference

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.

31 March 2020

1 reference

Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras

31 March 2020

1 reference

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

31 March 2020

1 reference

Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis

31 March 2020

1 reference

Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.

31 March 2020

1 reference

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

31 March 2020

1 reference

Glycine potentiates the NMDA response in cultured mouse brain neurons

31 March 2020

1 reference

D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices.

31 March 2020

1 reference

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

31 March 2020

1 reference

Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission

31 March 2020

1 reference

N-methyl-D-aspartic acid receptor structure and function

31 March 2020

1 reference

Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation.

31 March 2020

1 reference

Emerging treatments for stroke in humans

31 March 2020

1 reference

31 March 2020

Neuroprotective therapy

1 reference

Neuroprotection in acute ischaemic stroke. Current status and future potential

31 March 2020

1 reference

Low affinity channel blocking (uncompetitive) NMDA receptor antagonists as therapeutic agents--toward an understanding of their favorable tolerability

31 March 2020

1 reference

Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies

31 March 2020

1 reference

Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels

31 March 2020

1 reference

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

31 March 2020

1 reference

Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells

31 March 2020

1 reference

Trapping channel block of NMDA-activated responses by amantadine and memantine

31 March 2020

1 reference

Amantadine inhibits NMDA receptors by accelerating channel closure during channel block.

31 March 2020

1 reference

Interaction of memantine and amantadine with agonist-unbound NMDA-receptor channels in acutely isolated rat hippocampal neurons.

31 March 2020

1 reference

The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

31 March 2020

1 reference

Memantine (1-amino-3,5-dimethyladamantane) blocks the serotonin-induced depolarization response in a neuronal cell line

31 March 2020

1 reference

Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data

31 March 2020

1 reference

Memantine prevents HIV coat protein-induced neuronal injury in vitro

31 March 2020

1 reference

Delayed administration of memantine prevents N-methyl-D-aspartate receptor-mediated neurotoxicity

31 March 2020

1 reference

Molecular basis of glutamate toxicity in retinal ganglion cells.

31 March 2020

1 reference

Memantine reduces alterations to the mammalian retina, in situ, induced by ischemia

31 March 2020

1 reference

Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial

31 March 2020

1 reference

Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).

31 March 2020

1 reference

Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors

31 March 2020

1 reference

Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

31 March 2020

1 reference

Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging

31 March 2020

1 reference

Turning down, but not off.

31 March 2020

1 reference

Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine

31 March 2020

1 reference

NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury

31 March 2020

1 reference

Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins

31 March 2020

1 reference

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

31 March 2020

1 reference

Molecular diversity of glutamate receptors and implications for brain function

31 March 2020

1 reference

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

31 March 2020

1 reference

Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes

31 March 2020

1 reference

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

31 March 2020

1 reference

Magnesium gates glutamate-activated channels in mouse central neurones

31 March 2020

1 reference

Identification by mutagenesis of a Mg(2+)-block site of the NMDA receptor channel

31 March 2020

1 reference

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels

31 March 2020

1 reference

The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro

31 March 2020

1 reference

The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease

31 March 2020

1 reference

Alzheimer's disease: genes, proteins, and therapy

31 March 2020

1 reference

Organic calcium channel blockers enhance [3H]purine release from rat brain cortical synaptosomes

31 March 2020

1 reference

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

31 March 2020

1 reference

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

31 March 2020

1 reference

Rapid appearance of beta-amyloid precursor protein immunoreactivity in glial cells following excitotoxic brain injury

31 March 2020

1 reference

beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis

31 March 2020

1 reference

Modifications of neuronal phosphorylated tau immunoreactivity induced by NMDA toxicity

31 March 2020

1 reference

Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40).

31 March 2020

1 reference

Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease.

31 March 2020

1 reference

Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1958

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

538277

1053003644

0 references

538277

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference