(Q22254660)

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The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q

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The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q (English)

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Rho GTPase activating protein 26

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GOA release 2020-03-11

GTPase activator activity

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GOA release 2020-03-11

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based on heuristic

inferred from title

myeloid leukemia

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based on heuristic

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author name string

A Borkhardt

1

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A

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Borkhardt

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PubMed publication ID

8 February 2023

S Bojesen

2

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S

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Bojesen

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PubMed publication ID

8 February 2023

O A Haas

3

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O A

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Haas

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PubMed publication ID

8 February 2023

U Fuchs

4

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U

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Fuchs

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PubMed publication ID

8 February 2023

D Bartelheimer

5

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D

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Bartelheimer

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PubMed publication ID

8 February 2023

I F Loncarevic

6

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I F

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Loncarevic

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PubMed publication ID

8 February 2023

R M Bohle

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R M

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Bohle

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PubMed publication ID

8 February 2023

J Harbott

8

author given names

J

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Harbott

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PubMed publication ID

8 February 2023

R Repp

9

author given names

R

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Repp

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PubMed publication ID

8 February 2023

U Jaeger

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U

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Jaeger

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PubMed publication ID

8 February 2023

S Viehmann

11

author given names

S

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Viehmann

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PubMed publication ID

8 February 2023

T Henn

12

author given names

T

author last names

Henn

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PubMed publication ID

8 February 2023

P Korth

13

author given names

P

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Korth

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PubMed publication ID

8 February 2023

D Scharr

14

author given names

D

author last names

Scharr

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PubMed publication ID

8 February 2023

F Lampert

15

author given names

F

author last names

Lampert

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PubMed publication ID

8 February 2023

language of work or name

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publication date

1 August 2000

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Proceedings of the National Academy of Sciences of the United States of America

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97

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16

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9168-73

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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

1 reference

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19 March 2017

Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth

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Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

1 reference

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19 March 2017

An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

1 reference

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19 March 2017

Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS)

1 reference

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19 March 2017

Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia

1 reference

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Tumour suppressor genes in disease and therapy

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19 March 2017

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

1 reference

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7 April 2017

The role of chromosome translocations in leukemogenesis.

1 reference

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27 September 2017

Mll rearrangements in haematological malignancies: lessons from clinical and biological studies

1 reference

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27 September 2017

Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

Activity and nature of p21(WAF1) complexes during the cell cycle

1 reference

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27 September 2017

Novel genes mapping to the critical region of the 5q- syndrome.

1 reference

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27 September 2017

Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1-1.5 Mb and preparation of a PAC-based physical map.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

The Ras superfamily of GTPases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

The isolation of a yeast artificial chromosome which spans the chromosome 11q23 region involved in a number of translocations in acute leukaemias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

Cancer genes and hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

Chimaeric oncoproteins resulting from chromosomal translocations in acute lymphoblastic leukaemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

The 5q-syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

Deletions of chromosome 5 in malignant myeloid disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

5q-, twenty-five years later: a synopsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

27 September 2017

Acute myeloid leukemia with t(5;11): two case reports.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

30 May 2018

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

30 May 2018

Anatomy of the 5q- deletion: different sex ratios and deleted 5q bands in MDS and AML.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

30 May 2018

Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

30 May 2018

The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16840

30 May 2018

Chromosomal translocations in human cancer.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.150079597

21 January 2018

Chromosome 11q23 translocations in both infant and adult acute leukemias are detected by in situ hybridization with a yeast artificial chromosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/10908648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Mapping of Uncharacteristically Small 5q Deletions in Two Patients with the 5q- Syndrome: Delineation of the Critical Region on 5q and Identification of a 5q- Breakpoint

1 reference

https://pubmed.ncbi.nlm.nih.gov/10908648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new fingerprint method for sequence analysis of chromosomal translocations at the genomic DNA level

1 reference

https://pubmed.ncbi.nlm.nih.gov/10908648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants

1 reference

https://pubmed.ncbi.nlm.nih.gov/10908648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Checking on the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/10908648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q- chromosome in some patients with the 5q- syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/10908648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5q-: pathogenetic importance of the common deleted region and clinical consequences of the entire deleted segment

1 reference

https://pubmed.ncbi.nlm.nih.gov/10908648

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.150079597

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2000PNAS...97.9168B

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release_nyodtgcn45bhffnkqum76slaum

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PMC publication ID

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PubMed publication ID

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