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Sepsis: rethinking the approach to clinical research
scientific article
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instance of
scholarly article
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review article
1 reference
stated in
Europe PubMed Central
title
Sepsis: rethinking the approach to clinical research
(English)
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main subject
cell biology
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sepsis
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author name string
J. C. Marshall
series ordinal
1
author given names
John C
author last names
Marshall
1 reference
stated in
PubMed
PubMed publication ID
18171697
retrieved
8 February 2023
language of work or name
English
0 references
publication date
8 November 2007
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published in
Journal of Leukocyte Biology
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volume
83
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issue
3
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page(s)
471-482
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cites work
Microbial infection and the septic response in critical surgical illness. Sepsis, not infection, determines outcome
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Crossref
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7 January 2021
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The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study
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Crossref
reference URL
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Long-term Survival and Function After Suspected Gram-negative Sepsis
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Crossref
reference URL
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Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial
1 reference
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Crossref
reference URL
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7 January 2021
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Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study
1 reference
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Crossref
reference URL
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7 January 2021
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Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
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inferred from DOI database lookup
Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome.
1 reference
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Crossref
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Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial
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Crossref
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Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials
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Crossref
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Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis
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Crossref
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The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death
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Crossref
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Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.
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Crossref
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Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
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Crossref
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Endotoxemia after major vascular operations
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Crossref
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7 January 2021
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Signaling pathways activated by microorganisms
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Crossref
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7 January 2021
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Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Pathogen recognition and innate immunity
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Crossref
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7 January 2021
based on heuristic
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Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors
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Crossref
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inferred from DOI database lookup
Historic perspectives on the relative contributions of diastolic and systolic blood pressure elevation to cardiovascular risk profile
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Diagnosis of nosocomial bacterial pneumonia in intubated patients undergoing ventilation: comparison of the usefulness of bronchoalveolar lavage and the protected specimen brush
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Crossref
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7 January 2021
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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
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Crossref
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https://api.crossref.org/works/10.1189%2FJLB.0607380
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based on heuristic
inferred from DOI database lookup
Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group
1 reference
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Crossref
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https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
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inferred from DOI database lookup
Acute lung injury and the acute respiratory distress syndrome: a clinical review
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Macrophage migration inhibitory factor (mif) transcription is significantly elevated in Caenorhabditis elegans dauer larvae.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
A network-based analysis of systemic inflammation in humans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
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inferred from DOI database lookup
The innate signaling of dangers and the dangers of innate signaling
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Crossref
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https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
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Such stuff as dreams are made on: mediator-directed therapy in sepsis
1 reference
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Crossref
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https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
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inferred from DOI database lookup
Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.
1 reference
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Crossref
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https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
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inferred from DOI database lookup
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
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inferred from DOI database lookup
Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
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inferred from DOI database lookup
Genetic and environmental influences on premature death in adult adoptees
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Crossref
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https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
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inferred from DOI database lookup
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy and safety of recombinant human activated protein C for severe sepsis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Drotrecogin Alfa (Activated) in Severe Sepsis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The epidemiology of sepsis in the United States from 1979 through 2000
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endotoxin and antiendotoxin antibodies in patients with acute pancreatitis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The fecal flora of various strains of mice. Its bearing on their susceptibility to endotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clinical trials of immunomodulatory therapies in severe sepsis and septic shock
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
Limulus amebocyte lysate assay for detection of endotoxin in patients with sepsis syndrome. AMCC Sepsis Project Working Group.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
Increased gene expression of a cytokine-related molecule and profilin after activation of Suberites domuncula cells with xenogeneic sponge molecule(s).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Empiric antimicrobial therapy in critical illness: results of a surgical infection society survey
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Primary Role of Lymphoreticnlar Cells in the Mediation of Host Responses to Bacterial Endotoxim
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
The ancient riddle of sigma eta psi iota sigma (sepsis).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
New strategies for clinical trials in patients with sepsis and septic shock
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
Recombinant human activated protein C in sepsis: inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
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7 January 2021
based on heuristic
inferred from DOI database lookup
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sepsis in European intensive care units: results of the SOAP study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neutralization of tumor necrosis factor in preclinical models of sepsis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influence of Comorbid Conditions on Long-Term Mortality After Pneumonia in Older People
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a plasmid-encoded gene from Haemophilus ducreyi which confers NAD independence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physiological functions of caspases beyond cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Meta-analysis: Intravenous Immunoglobulin in Critically Ill Adult Patients with Sepsis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.0607380
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1189/JLB.0607380
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4293089
OpenCitations bibliographic resource ID
4293089
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4293089
PubMed publication ID
18171697
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4293089
ResearchGate publication ID
5677673
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