(Q22675856)

English

somatotropin

mammalian protein found in Homo sapiens

GH1
growth hormone B5
GH
pituitary growth hormone
Growth hormone
GH-N

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Somatotropin/prolactin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01241

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01241

Somatotropin hormone, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

growth factor activity

determination method

1 reference

27 March 2018

A membrane-fixed, truncated isoform of the human growth hormone receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

growth hormone receptor binding

determination method

5 references

27 March 2018

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

27 March 2018

Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

27 March 2018

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

27 March 2018

Growth hormone receptor and serum binding protein: purification, cloning and expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

27 March 2018

Hepatic Binding of Human and Bovine Growth Hormones and Ovine Prolactin in the Dwarf “Little” Mouse*

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

growth hormone receptor binding

determination method

6 references

8 April 2019

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Growth hormone receptor and serum binding protein: purification, cloning and expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Hepatic Binding of Human and Bovine Growth Hormones and Ovine Prolactin in the Dwarf “Little” Mouse*

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

hormone activity

determination method

extracellular space

determination method

1 reference

27 March 2018

GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

growth hormone receptor complex

determination method

3 references

8 April 2019

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

collagen-containing extracellular matrix

determination method

1 reference

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

biological process

growth hormone receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

response to estradiol

determination method

1 reference

8 April 2019

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of MAP kinase activity

determination method

1 reference

8 April 2019

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of receptor internalization

determination method

1 reference

8 April 2019

A membrane-fixed, truncated isoform of the human growth hormone receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

bone maturation

determination method

1 reference

8 April 2019

High-dose GH treatment limited to the prepubertal period in young children with idiopathic short stature does not increase adult height

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

growth hormone receptor signaling pathway

determination method

1 reference

27 March 2018

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

positive regulation of insulin-like growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of multicellular organism growth

determination method

3 references

8 April 2019

Heterogeneous growth hormone (GH) gene mutations in familial GH deficiency

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

High-dose GH treatment limited to the prepubertal period in young children with idiopathic short stature does not increase adult height

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

27 March 2018

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

positive regulation of phosphatidylinositol 3-kinase signaling

determination method

1 reference

8 April 2019

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of receptor signaling pathway via JAK-STAT

determination method

2 references

27 March 2018

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

27 March 2018

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

2 references

27 March 2018

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

27 March 2018

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01241&geneProductId=UniProtKB:P01241

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of glucose transmembrane transport

determination method

1 reference

8 April 2019

Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis?

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

response to nutrient levels

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

3 references

8 April 2019

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of growth

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of receptor signaling pathway via JAK-STAT

determination method

3 references

8 April 2019

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

animal organ development

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01241

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

Somatotropin hormone, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01241

Identifiers

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000312673

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000312673

ENSP00000343791

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000343791

ENSP00000408486

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408486

ENSP00000339278

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000339278

ENSP00000481276

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000481276

New York Times topic ID

subject/human-growth-hormone

0 references

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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