(Q22676913)

hydrolase activity, acting on glycosyl bonds

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

acid sphingomyelin phosphodiesterase activity

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

sphingomyelin phosphodiesterase activity

IDA

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Molecular basis of acid sphingomyelinase dificiency in a patient with Niemann-Pick disease type A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

phosphoric diester hydrolase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

acid sphingomyelin phosphodiesterase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

IDA

extracellular exosome

1 reference

8 April 2019

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

termination of signal transduction

HDA

biological process

1 reference

8 April 2019

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

glycosphingolipid metabolic process

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

positive regulation of protein dephosphorylation

TAS

1 reference

8 April 2019

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

ceramide biosynthetic process

IMP

3 references

26 September 2017

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

26 September 2017

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17405&geneProductId=UniProtKB:P17405

nervous system development

IDA

1 reference

8 April 2019

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

negative regulation of MAP kinase activity

TAS

1 reference

8 April 2019

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

positive regulation of apoptotic process

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

sphingomyelin metabolic process

TAS

1 reference

8 April 2019

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

sphingomyelin catabolic process

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

ceramide biosynthetic process

4 references

8 April 2019

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

ceramide metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

cholesterol metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17405

Calcineurin-like phosphoesterase domain, ApaH type

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17405

saposin B type domain

1 reference

stated in

InterPro Release 71.0