(Q22676929)

English

Nodal

mammalian protein found in Mus musculus

nodal

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Transforming growth factor-beta-related

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43021

Cystine-knot cytokine

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43021

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

receptor ligand activity

determination method

1 reference

14 February 2019

Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

transforming growth factor beta receptor binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

growth factor activity

determination method

2 references

type I activin receptor binding

determination method

3 references

extracellular region

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

extracellular space

determination method

4 references

24 April 2018

Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43021&geneProductId=UniProtKB:P43021

determination method

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43021&geneProductId=UniProtKB:P43021

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43021&geneProductId=UniProtKB:P43021

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43021&geneProductId=UniProtKB:P43021

determination method

extracellular space

determination method

5 references

14 February 2019

Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

biological process

trophectodermal cellular morphogenesis

determination method

1 reference

14 February 2019

Nodal regulates trophoblast differentiation and placental development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

regulation of apoptotic process

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

left lung morphogenesis

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

determination method

1 reference

14 February 2019

Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

neural fold formation

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

cell fate commitment

determination method

1 reference

14 February 2019

Cell fate decisions within the mouse organizer are governed by graded Nodal signals

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

maternal process involved in parturition

determination method

1 reference

14 February 2019

NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

endoderm development

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

transforming growth factor beta receptor signaling pathway involved in primitive streak formation

determination method

1 reference

14 February 2019

Control of early anterior-posterior patterning in the mouse embryo by TGF-β signalling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

floor plate morphogenesis

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

regulation of MAPK cascade

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

SMAD protein signal transduction

determination method

1 reference

24 April 2018

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43021&geneProductId=UniProtKB:P43021

determination method

epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification

determination method

1 reference

14 February 2019

Control of early anterior-posterior patterning in the mouse embryo by TGF-β signalling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

embryonic pattern specification

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

polarity specification of proximal/distal axis

determination method

1 reference

14 February 2019

Control of early anterior-posterior patterning in the mouse embryo by TGF-β signalling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

digestive system development

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

lung development

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

negative regulation of cell differentiation

determination method

1 reference

14 February 2019

Nodal regulates trophoblast differentiation and placental development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method

3 references

gastrulation with mouth forming second

determination method

1 reference

14 February 2019

Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

anatomical structure formation involved in morphogenesis

determination method

1 reference

14 February 2019

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

formation of anatomical boundary

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

embryonic placenta development

determination method

1 reference

14 February 2019

Nodal regulates trophoblast differentiation and placental development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Nodal regulates trophoblast differentiation and placental development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

tissue morphogenesis

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

BMP signaling pathway

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

nervous system development

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

nodal signaling pathway

determination method

1 reference

14 February 2019

Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

embryonic heart tube development

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

positive regulation of angiogenesis

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

determination method

1 reference

14 February 2019

Heart defects in X-linked heterotaxy: evidence for a genetic interaction of Zic3 with the nodal signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

embryonic process involved in female pregnancy

determination method

1 reference

14 February 2019

Nodal regulates trophoblast differentiation and placental development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

heart development

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

brain development

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

determination of left/right symmetry

determination method

7 references

14 February 2019

X-linked situs abnormalities result from mutations in ZIC3

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Nodal activity in the node governs left-right asymmetry

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Heart defects in X-linked heterotaxy: evidence for a genetic interaction of Zic3 with the nodal signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Left-right patterning of the mouse lateral plate requires nodal produced in the node

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

vasculature development

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

axial mesodermal cell fate specification

determination method

1 reference

14 February 2019

Control of early anterior-posterior patterning in the mouse embryo by TGF-β signalling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

maternal placenta development

determination method

1 reference

14 February 2019

NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

regulation of signal transduction

determination method

1 reference

14 February 2019

Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

trophectodermal cell differentiation

determination method

1 reference

14 February 2019

Nodal regulates trophoblast differentiation and placental development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

mesendoderm development

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Control of early anterior-posterior patterning in the mouse embryo by TGF-β signalling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

positive regulation of cell population proliferation

determination method

1 reference

14 February 2019

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

embryonic cranial skeleton morphogenesis

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

liver development

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

cell migration involved in gastrulation

determination method

1 reference

14 February 2019

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

anterior/posterior axis specification

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

14 February 2019

Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

determination method

1 reference

14 February 2019

Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

regulation of gastrulation

determination method

1 reference

14 February 2019

Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

primitive streak formation

determination method

1 reference

14 February 2019

Correct patterning of the primitive streak requires the anterior visceral endoderm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

negative regulation of cell development

determination method

1 reference

14 February 2019

Endogenous Nodal signaling regulates germ cell potency during mammalian testis development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

anterior/posterior pattern specification

determination method

5 references

14 February 2019

Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Nodal signalling in the epiblast patterns the early mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

14 February 2019

Heart defects in X-linked heterotaxy: evidence for a genetic interaction of Zic3 with the nodal signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

digestive tract morphogenesis

determination method

1 reference

14 February 2019

Genetic dissection of nodal function in patterning the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

inhibition of neuroepithelial cell differentiation

determination method

1 reference

14 February 2019

Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

regulation of signaling receptor activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

cell development

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43021

determination method

Transforming growth factor beta, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43021

Transforming growth factor-beta, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P43021

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000039653

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000039653

Sitelinks

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Wikisource(0 entries)

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Multilingual sites(0 entries)

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