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Nardilysin convertase
mammalian protein found in Homo sapiens
NRD convertase
NRD-C
nardilysin (N-arginine dibasic convertase)
NRDC
nardilysin
N-arginine dibasic convertase
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O43847
subclass of
protein
1 reference
stated in
UniProt
retrieved
1 December 2016
UniProt protein ID
O43847
part of
metalloenzyme, LuxS/M16 peptidase-like
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O43847
Peptidase M16, N-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Peptidase M16, middle/third domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Peptidase M16, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Peptidase M16, zinc-binding site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O43847
encoded by
NRDC
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O43847
molecular function
peptidase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IEA
protein binding
determination method
IPI
2 references
retrieved
8 April 2019
stated in
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IPI
retrieved
8 April 2019
stated in
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IPI
catalytic activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IEA
metallopeptidase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IEA
hydrolase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IEA
metal ion binding
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IEA
epidermal growth factor binding
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Precursor convertases in the secretory pathway, cytosol and extracellular milieu
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
TAS
metalloendopeptidase activity
determination method
IEA
NAS
2 references
retrieved
8 April 2019
stated in
Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IEA
cell component
cell surface
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Precursor convertases in the secretory pathway, cytosol and extracellular milieu
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
TAS
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Precursor convertases in the secretory pathway, cytosol and extracellular milieu
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
TAS
mitochondrion
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IDA
biological process
positive regulation of membrane protein ectodomain proteolysis
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IDA
cell population proliferation
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Precursor convertases in the secretory pathway, cytosol and extracellular milieu
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
TAS
neuromuscular junction development
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
TAS
cell migration
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
TAS
regulation of endopeptidase activity
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IDA
proteolysis
determination method
NAS
IEA
3 references
retrieved
8 April 2019
stated in
Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O43847
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
IEA
negative regulation of cold-induced thermogenesis
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
Critical roles of nardilysin in the maintenance of body temperature homoeostasis
GOA
curator
YuBioLab
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43847
determination method
ISS
has part(s)
Peptidase M16, middle/third domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O43847
peptidase M16, C-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O43847
peptidase M16, N-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O43847
peptidase M16, zinc-binding site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O43847
Identifiers
RefSeq protein ID
NP_001095132
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4898
NP_001229290
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4898
NP_002516
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4898
UniProt protein ID
O43847
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O43847
Ensembl protein ID
ENSP00000262679
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000262679
ENSP00000346890
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000346890
ENSP00000398464
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000398464
ENSP00000442262
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000442262
ENSP00000444416
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000444416
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Wikiquote
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