(Q22678676)

Immunoglobulin-like domain superfamily

1 reference

inferred from GOA cell component → membrane

membrane protein

1 reference

based on heuristic

Signaling lymphocytic activation molecule, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

A novel receptor involved in T-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

TAS

virus receptor activity

1 reference

8 April 2019

13 references

8 April 2019

Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

Side-chain dynamics of the SAP SH2 domain correlate with a binding hot spot and a region with conformational plasticity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

SAP couples Fyn to SLAM immune receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

Characterization of a new disease-causing mutation of SH2D1A in a family with X-linked lymphoproliferative disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

Adherens junction protein nectin-4 is the epithelial receptor for measles virus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

Disease-causing SAP mutants are defective in ligand binding and protein folding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

8 April 2019

Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

transmembrane signaling receptor activity

IPI

1 reference

8 April 2019

A novel receptor involved in T-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

identical protein binding

TAS

3 references

17 October 2017

Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

17 October 2017

A secreted protein microarray platform for extracellular protein interaction discovery

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

external side of plasma membrane

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

HDA

biological process

adaptive immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

immune system process

1 reference

8 April 2019

natural killer cell proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

T-helper 1 cell cytokine production

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

negative regulation of interleukin-6 production

1 reference

8 April 2019

SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

positive regulation of JNK cascade

1 reference

8 April 2019

CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

negative regulation of CD40 signaling pathway

1 reference

8 April 2019

SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

negative regulation of T cell cytokine production

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

myeloid dendritic cell activation involved in immune response

1 reference

8 April 2019

SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

regulation of vesicle fusion

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

positive regulation of cell population proliferation

1 reference

8 April 2019

A novel receptor involved in T-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

positive regulation of ERK1 and ERK2 cascade

TAS

1 reference

8 April 2019

CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

lymphocyte activation

1 reference

8 April 2019

viral entry into host cell

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

negative regulation of tumor necrosis factor production

1 reference

8 April 2019

SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

innate immune response

1 reference

8 April 2019

regulation of catalytic activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

positive regulation of activated T cell proliferation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

negative regulation of interleukin-12 production

1 reference

8 April 2019

SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13291

natural killer cell differentiation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

1 reference

17 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

leukocyte chemotaxis involved in inflammatory response

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

positive regulation of macrophage chemotaxis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

positive regulation of dendritic cell chemotaxis

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13291&geneProductId=UniProtKB:Q13291

immunoglobulin-like domain

has part(s)

1 reference

Signaling lymphocytic activation molecule, N-terminal

1 reference

D12.776.543.750.705.970.500

Identifiers

MeSH descriptor ID

D000071177

subject named as

Signaling Lymphocytic Activation Molecule Family Member 1

0 references

MeSH tree code

D12.776.395.550.736.500

0 references

D12.776.543.550.746.500

0 references

0 references

D09.400.430.890.736.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference