(Q22679878)

English

Pleckstrin

mammalian protein found in Homo sapiens

pleckstrin
PLEK
platelet 47 kDa protein
p47

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08567

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08567

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08567

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pleckstrin 1, DEP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DEP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

1 reference

26 September 2017

Chemical cross-linking of pleckstrin in human platelets: evidence for oligomerization of the protein and its dissociation by protein kinase C

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

phosphatidylinositol-3,4-bisphosphate binding

determination method

1 reference

26 September 2017

Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

protein binding

determination method

3 references

26 September 2017

Proteomic identification of pleckstrin-associated proteins in platelets: possible interactions with actin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

26 September 2017

Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

26 September 2017

Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

protein kinase C binding

determination method

1 reference

26 September 2017

Phosphorylation of human pleckstrin on Ser-113 and Ser-117 by protein kinase C

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

determination method

2 references

26 September 2017

Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

26 September 2017

Chemical cross-linking of pleckstrin in human platelets: evidence for oligomerization of the protein and its dissociation by protein kinase C

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

determination method

1 reference

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

ruffle membrane

determination method

1 reference

26 September 2017

Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

extracellular region

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

biological process

actin cytoskeleton reorganization

determination method

1 reference

26 September 2017

Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

intracellular signal transduction

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

phospholipase C-inhibiting G protein-coupled receptor signaling pathway

determination method

1 reference

26 September 2017

Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

phosphatidylinositol metabolic process

determination method

1 reference

26 September 2017

Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

regulation of cell diameter

determination method

1 reference

26 September 2017

Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

ruffle organization

determination method

1 reference

26 September 2017

Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

positive regulation of inositol-polyphosphate 5-phosphatase activity

determination method

1 reference

26 September 2017

Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

cell projection organization

determination method

1 reference

26 September 2017

Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

hematopoietic progenitor cell differentiation

determination method

1 reference

26 September 2017

Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

integrin-mediated signaling pathway

determination method

1 reference

26 September 2017

Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

negative regulation of calcium-mediated signaling

determination method

1 reference

26 September 2017

Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

positive regulation of actin filament bundle assembly

determination method

1 reference

26 September 2017

Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

negative regulation of G protein-coupled receptor signaling pathway

determination method

1 reference

26 September 2017

Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

platelet aggregation

determination method

3 references

26 September 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

26 September 2017

Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

cortical actin cytoskeleton organization

determination method

1 reference

26 September 2017

Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

negative regulation of inositol phosphate biosynthetic process

determination method

2 references

26 September 2017

Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

26 September 2017

Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08567&geneProductId=UniProtKB:P08567

determination method

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08567

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08567

Pleckstrin 1, DEP domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08567

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000234313

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000234313

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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