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(Q22680288)
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SH2 domain containing 1B2
mammalian protein found in Mus musculus
EAT-2-related transducer
EAT-2B
Sh2d1b2
SH2 domain-containing protein 1B2
ERT
SH2 domain protein 1B2
In more languages
default values for all languages
No label defined
No description defined
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q45HK4
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
Q45HK4
part of
SH2 domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q45HK4
EAT-2, SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH2 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q45HK4
encoded by
Sh2d1b2
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q45HK4
molecular function
protein binding
determination method
IPI
3 references
retrieved
14 February 2019
stated in
Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IPI
retrieved
14 February 2019
stated in
Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IPI
retrieved
14 February 2019
stated in
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IPI
cell component
cytoplasm
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q45HK4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IEA
cellular component
determination method
ND
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
ND
biological process
negative regulation of natural killer cell mediated cytotoxicity
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IMP
peptidyl-tyrosine phosphorylation
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IDA
innate immune response
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q45HK4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IEA
regulation of natural killer cell activation
determination method
IGI
1 reference
retrieved
14 February 2019
stated in
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IGI
adaptive immune response
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q45HK4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IEA
positive regulation of natural killer cell mediated cytotoxicity
determination method
IGI
2 references
retrieved
14 February 2019
stated in
Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IGI
retrieved
14 February 2019
stated in
Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IGI
immune system process
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q45HK4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IEA
positive regulation of peptidyl-tyrosine phosphorylation
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q45HK4
determination method
IDA
has part(s)
SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q45HK4
EAT-2, SH2 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q45HK4
Identifiers
RefSeq protein ID
NP_001028671
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
545378
UniProt protein ID
Q45HK4
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q45HK4
Ensembl protein ID
ENSMUSP00000137939
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000137939
ENSMUSP00000125121
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSMUSP00000125121
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