(Q22683547)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99959

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99959

armadillo domain proteins

1 reference

based on heuristic

inferred from protein domain or family

Armadillo domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

sodium channel regulator activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

intermediate filament binding

ISS

1 reference

27 March 2018

Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

transmembrane transporter binding

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

3 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication

IPI

1 reference

8 April 2019

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

molecular adaptor activity

IC

1 reference

27 March 2018

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy

alpha-catenin binding

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly

IPI

protein kinase C binding

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

1 reference

27 March 2018

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

molecular adaptor activity

IDA

4 references

1 January 2018

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

integral component of membrane

cell component

1 reference

8 April 2019

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

3 references

27 March 2018

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

4 references

8 April 2019

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

messenger ribonucleoprotein complex

TAS

1 reference

8 April 2019

Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

3 references

8 April 2019

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

intermediate filament

5 references

8 April 2019

8 April 2019

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

4 references

8 April 2019

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

intermediate filament bundle assembly

biological process

1 reference

27 March 2018

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

cell communication by electrical coupling involved in cardiac conduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

ventricular cardiac muscle cell action potential

ISS

1 reference

8 April 2019

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

cardiac muscle cell action potential involved in contraction

1 reference

8 April 2019

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

1 reference

8 April 2019

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

cell-cell signaling involved in cardiac conduction

1 reference

27 March 2018

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

ventricular cardiac muscle tissue morphogenesis

1 reference

8 April 2019

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

1 reference

8 April 2019

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

positive regulation of sodium ion transport

IEA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

regulation of ventricular cardiac muscle cell action potential

ISS

1 reference

8 April 2019

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

maintenance of animal organ identity

1 reference

8 April 2019

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

protein localization to plasma membrane

TAS

1 reference

27 March 2018

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

4 references

27 March 2018

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99959&geneProductId=UniProtKB:Q99959

cell-cell junction assembly

IEA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

adherens junction maintenance

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

5 references

8 April 2019

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99959

physically interacts with

1 reference

https://thebiogrid.org/news/227

retrieved

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

BioGRID

has part(s)

Armadillo

1 reference

InterPro Release 71.0