(Q22695891)

English

Leptin

mammalian protein found in Mus musculus

Lep
obesity factor
leptin

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41160

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41160

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

hormone activity

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

peptide hormone receptor binding

determination method

3 references

determination method

1 reference

14 February 2019

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

extracellular region

determination method

3 references

extracellular space

determination method

7 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Endocrine regulation of energy metabolism by the skeleton

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Role of the fatty acid binding protein mal1 in obesity and insulin resistance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Hypothalamic CART is a new anorectic peptide regulated by leptin

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

extracellular space

determination method

8 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Role of the fatty acid binding protein mal1 in obesity and insulin resistance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Endocrine regulation of energy metabolism by the skeleton

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Hypothalamic CART is a new anorectic peptide regulated by leptin

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

biological process

regulation of protein phosphorylation

determination method

1 reference

14 February 2019

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

cellular response to retinoic acid

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

negative regulation of glucagon secretion

determination method

1 reference

14 February 2019

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

tyrosine phosphorylation of STAT protein

determination method

1 reference

24 April 2018

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

regulation of intestinal cholesterol absorption

determination method

1 reference

14 February 2019

Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

T cell differentiation

determination method

1 reference

14 February 2019

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

central nervous system neuron development

determination method

1 reference

14 February 2019

NMDA and AMPA glutamate receptor subtypes in the thoracic spinal cord in lean and obese-diabetic ob/ob mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

circadian rhythm

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

glucose metabolic process

determination method

1 reference

14 February 2019

Role of the fatty acid binding protein mal1 in obesity and insulin resistance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

response to ethanol

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

14 February 2019

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

glucose homeostasis

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of insulin secretion

determination method

1 reference

14 February 2019

Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

interleukin-6 production

determination method

1 reference

14 February 2019

Leptin regulates proinflammatory immune responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of steroid biosynthetic process

determination method

1 reference

14 February 2019

Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

insulin secretion

determination method

1 reference

14 February 2019

VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of fat cell differentiation

determination method

1 reference

14 February 2019

Mex3c mutation reduces adiposity and increases energy expenditure

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

response to vitamin E

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

response to insulin

determination method

1 reference

24 April 2018

VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

response to nutrient levels

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of tumor necrosis factor production

determination method

1 reference

14 February 2019

Leptin regulates proinflammatory immune responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of protein import into nucleus

determination method

1 reference

14 February 2019

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of brown fat cell differentiation

determination method

1 reference

14 February 2019

SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

fatty acid beta-oxidation

determination method

1 reference

14 February 2019

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of metabolic process

determination method

1 reference

14 February 2019

Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

hormone metabolic process

determination method

1 reference

14 February 2019

Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of MAPK cascade

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

cellular response to L-ascorbic acid

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

response to nutrient

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

bile acid metabolic process

determination method

1 reference

14 February 2019

Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

female pregnancy

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

cholesterol metabolic process

determination method

1 reference

14 February 2019

Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of follicle-stimulating hormone secretion

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

negative regulation of appetite

determination method

1 reference

14 February 2019

Hypothalamic CART is a new anorectic peptide regulated by leptin

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of protein localization to nucleus

determination method

1 reference

14 February 2019

Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

adipose tissue development

determination method

1 reference

14 February 2019

In vivo modulation of Hmgic reduces obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

determination method

1 reference

14 February 2019

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

interleukin-12 production

determination method

1 reference

14 February 2019

Leptin regulates proinflammatory immune responses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of receptor signaling pathway via JAK-STAT

determination method

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

positive regulation of luteinizing hormone secretion

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of gluconeogenesis

determination method

1 reference

14 February 2019

Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

response to estradiol

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

adult feeding behavior

determination method

1 reference

14 February 2019

Hypothalamic CART is a new anorectic peptide regulated by leptin

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

response to hypoxia

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

eating behavior

determination method

1 reference

14 February 2019

Dopamine is required for hyperphagia in Lep(ob/ob) mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of cytokine production

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

lipid metabolism

determination method

1 reference

24 April 2018

Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

response to activity

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

cellular response to leptin stimulus

determination method

3 references

regulation of cell cycle

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

signal transduction

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of bone remodeling

determination method

1 reference

14 February 2019

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

intestinal absorption

determination method

3 references

positive regulation of p38MAPK cascade

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of natural killer cell proliferation

determination method

3 references

regulation of nitric-oxide synthase activity

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of natural killer cell activation

determination method

3 references

regulation of endothelial cell proliferation

determination method

3 references

activation of protein kinase C activity

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of phosphatidylinositol 3-kinase signaling

determination method

4 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

24 April 2018

SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41160&geneProductId=UniProtKB:P41160

determination method

positive regulation of TOR signaling

determination method

3 references

negative regulation of autophagy

determination method

3 references

regulation of angiogenesis

determination method

3 references

negative regulation of glucose import

determination method

3 references

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of natural killer cell mediated cytotoxicity

determination method

3 references

regulation of cytokine production involved in inflammatory response

determination method

3 references

prostaglandin secretion

determination method

3 references

sexual reproduction

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of signaling receptor activity

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

response to dietary excess

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

energy reserve metabolic process

determination method

3 references

determination method

leptin-mediated signaling pathway

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

negative regulation of appetite by leptin-mediated signaling pathway

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

determination of adult lifespan

determination method

1 reference

14 February 2019

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of phosphatidylinositol 3-kinase signaling

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of receptor signaling pathway via JAK-STAT

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of lipid biosynthetic process

determination method

1 reference

14 February 2019

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

positive regulation of cold-induced thermogenesis

determination method

1 reference

14 February 2019

Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

aorta development

determination method

1 reference

14 February 2019

Increased aortic stiffness and attenuated lysyl oxidase activity in obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

regulation of catalytic activity

determination method

1 reference

14 February 2019

Increased aortic stiffness and attenuated lysyl oxidase activity in obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

elastin metabolic process

determination method

1 reference

14 February 2019

Increased aortic stiffness and attenuated lysyl oxidase activity in obesity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41160

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000067046

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000067046

ENSMUSP00000130087

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000130087

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