(Q24291085)

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Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism

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6 November 2019

Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism (English)

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6 November 2019

DNA-(apurinic or apyrimidinic site) lyase

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GOA release 2020-03-11

metal ion binding

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GOA release 2020-03-11

6

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6 November 2019

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Beernink PT

1

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6 November 2019

Segelke BW

2

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6 November 2019

Hadi MZ

3

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6 November 2019

Erzberger JP

4

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Wilson DM 3rd

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1 April 2001

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6 November 2019

Journal of Molecular Biology

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6 November 2019

307

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6 November 2019

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6 November 2019

1023-1034

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6 November 2019

Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism

1 reference

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Intragenic suppression of an active site mutation in the human apurinic/apyrimidinic endonuclease

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The role of Mg2+ and specific amino acid residues in the catalytic reaction of the major human abasic endonuclease: new insights from EDTA-resistant incision of acyclic abasic site analogs and site-directed mutagenesis.

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Mapping the protein-DNA interface and the metal-binding site of the major human apurinic/apyrimidinic endonuclease

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PvuII endonuclease contains two calcium ions in active sites

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X-ray structure of the DNase I-d(GGTATACC)2 complex at 2.3 A resolution

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Raster3D: photorealistic molecular graphics

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7 January 2021

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Going APE over ref-1.

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Mammalian base excision repair and DNA polymerase beta

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The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal

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Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

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Divalent metal ions at the active sites of the EcoRV and EcoRI restriction endonucleases.

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Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A

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NMR studies of abasic sites in DNA duplexes: deoxyadenosine stacks into the helix opposite acyclic lesions

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Single-turnover analysis of mutant human apurinic/apyrimidinic endonuclease

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7 January 2021

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Metal Activation of Enzymes in Nucleic Acid Biochemistry

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

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7 January 2021

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DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

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7 January 2021

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Structure and function of the multifunctional DNA-repair enzyme exonuclease III

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Errors in protein structures

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Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.

1 reference

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How does RNase H recognize a DNA.RNA hybrid?

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The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains

1 reference

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AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1 reference

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7 January 2021

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Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA

1 reference

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7 January 2021

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Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product

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Rapid dissociation of human apurinic endonuclease (Ape1) from incised DNA induced by magnesium

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A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA.

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Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity

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The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites

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Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA

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Removal of 3'-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1

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Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity

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Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1

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3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends

1 reference

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Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.

1 reference

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1 reference

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Identifiers

10.1006/JMBI.2001.4529

1 reference

Europe PubMed Central

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6 November 2019

1 reference

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6 November 2019

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