(Q24291656)

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A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC

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A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC (English)

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GIPC PDZ domain containing family, member 1

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GOA release 2020-03-11

Transforming growth factor, beta receptor III

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GOA release 2020-03-11

5

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author name string

G C Blobe

1

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X Liu

2

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S J Fang

3

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T How

4

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language of work or name

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publication date

26 October 2001

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Journal of Biological Chemistry

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276

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39608-17

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43

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Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration

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Expression cloning and characterization of the TGF-beta type III receptor

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

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Initial sequencing and analysis of the human genome

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Ubiquitin-dependent degradation of TGF-beta-activated smad2.

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The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

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Role of transforming growth factor beta in human disease

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Production of high-titer helper-free retroviruses by transient transfection

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GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP

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Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor beta 2

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Expression of transforming growth factor beta type III receptor suppresses tumorigenicity of human breast cancer MDA-MB-231 cells

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A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF

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Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

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Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

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Different sensitivity of the transforming growth factor-beta cell cycle arrest pathway to c-Myc and MDM-2.

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Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling

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PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)

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PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B

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Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton

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GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways

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TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

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TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

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