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SCAP ligands are potent new lipid-lowering drugs
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instance of
scholarly article
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title
SCAP ligands are potent new lipid-lowering drugs
(English)
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main subject
SREBF chaperone
1 reference
stated in
GOA release 2020-03-11
positive regulation of gene expression
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stated in
GOA release 2020-03-11
author name string
T Grand-Perret
series ordinal
1
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A Bouillot
series ordinal
2
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A Perrot
series ordinal
3
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S Commans
series ordinal
4
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M Walker
series ordinal
5
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M Issandou
series ordinal
6
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language of work or name
English
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publication date
December 2001
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published in
Nature Medicine
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volume
7
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issue
12
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page(s)
1332-8
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cites work
An evidence-based assessment of the NCEP Adult Treatment Panel II guidelines. National Cholesterol Education Program
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A receptor-mediated pathway for cholesterol homeostasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a novel sterol-independent regulatory element in the human low density lipoprotein receptor promoter
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Several different upstream promoter elements can potentiate transactivation by the BPV-1 E2 protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of gene expression by SREBP and SCAP.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transport-Dependent Proteolysis of SREBP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolic modes of action of the statins in the hyperlipoproteinemias
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Statins: effective antiatherosclerotic therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The evolving role of statins in the management of atherosclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel lipid-regulating drugs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Current, new and future treatments in dyslipidaemia and atherosclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel approaches to lipid lowering: what is on the horizon?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Statin therapy and reductions in low-density lipoprotein cholesterol: initial clinical data on the potent new statin Rosuvastatin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Co-translational degradation of apolipoprotein B100 by the proteasome is prevented by microsomal triglyceride transfer protein. Synchronized translation studies on HepG2 cells treated with an inhibitor of microsomal triglyceride transfer protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1201-1332
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NM1201-1332
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Dimensions Publication ID
1008089262
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PubMed publication ID
11726974
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ResearchGate publication ID
11628836
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