(Q24292347)

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Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

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Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription (English)

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TXK tyrosine kinase

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GOA release 2020-03-11

positive regulation of interferon-gamma-mediated signaling pathway

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GOA release 2020-03-11

author name string

Yuko Takeba

1

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Hiroko Nagafuchi

2

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Mitsuhiro Takeno

3

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Jun-ichi Kashiwakura

4

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Noboru Suzuki

5

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language of work or name

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publication date

1 March 2002

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Journal of Immunology

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168

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5

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2365-70

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Possible correction of abnormal rheumatoid arthritis synovial cell function by jun D transfection in vitro

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Tec family of protein-tyrosine kinases: an overview of their structure and function

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional diversity of helper T lymphocytes

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulatory intramolecular association in a tyrosine kinase of the Tec family

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional analysis of the T-cell-restricted protein tyrosine kinase Txk.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the m4 cholinergic muscarinic receptor gene and its promoter

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Retinoic acid-induced transcriptional modulation of the human interferon-gamma promoter.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Acquisition of lymphokine-producing phenotype by CD4+ T cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.5.2365

7 January 2021

based on heuristic

inferred from DOI database lookup

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