(Q24293419)

English

Identification of bioactivating enzymes involved in the hydrolysis of laninamivir octanoate, a long-acting neuraminidase inhibitor, in human pulmonary tissue

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scholarly article

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Identification of bioactivating enzymes involved in the hydrolysis of laninamivir octanoate, a long-acting neuraminidase inhibitor, in human pulmonary tissue (English)

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Lysophospholipase 1

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GOA release 2020-03-11

lipase activity

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GOA release 2020-03-11

author name string

Kumiko Koyama

1

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Yuji Ogura

2

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Daisuke Nakai

3

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Mihoko Watanabe

4

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Toshiko Munemasa

5

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Yuka Oofune

6

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Kazuishi Kubota

7

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Akira Shinagawa

8

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Takashi Izumi

9

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language of work or name

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publication date

June 2014

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Drug Metabolism and Disposition

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42

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6

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1031-8

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Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy

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Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

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Identity of the polymorphisms for esterase D and S-formylglutathione hydrolase in red blood cells

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Differential enzyme activities in human esterase D phenotypes

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The distribution of esterase D variants in different ethnic groups

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Impact of CYP2D6 genetic polymorphism on tramadol pharmacokinetics and pharmacodynamics

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A randomized double-blind controlled study of laninamivir compared with oseltamivir for the treatment of influenza in patients with chronic respiratory diseases

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Laninamivir octanoate for post-exposure prophylaxis of influenza in household contacts: a randomized double blind placebo controlled trial

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A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

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Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1.

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Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach

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Correlation profiling for determining kinase-substrate relationships.

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A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization

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Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.

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Sensitive multiplexed analysis of kinase activities and activity-based kinase identification

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Small-molecule inhibition of APT1 affects Ras localization and signaling

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Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips

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A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics

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Prodrugs: design and clinical applications.

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Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS

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A sialic acid-specific O-acetylesterase in human erythrocytes: possible identity with esterase D, the genetic marker of retinoblastomas and Wilson disease

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Purification, cDNA cloning, and regulation of lysophospholipase from rat liver

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A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)

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Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin

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Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivo

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Identification of a metabolizing enzyme in human kidney by proteomic correlation profiling

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Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

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Long-acting neuraminidase inhibitor laninamivir octanoate versus oseltamivir for treatment of influenza: A double-blind, randomized, noninferiority clinical trial

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Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate

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A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme

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CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity

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CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract

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Long-acting neuraminidase inhibitor laninamivir octanoate (CS-8958) versus oseltamivir as treatment for children with influenza virus infection

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Intrapulmonary distribution and pharmacokinetics of laninamivir, a neuraminidase inhibitor, after a single inhaled administration of its prodrug, laninamivir octanoate, in healthy volunteers

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Purification and properties of an esterase from the yeast Saccharomyces cerevisiae and identification of the encoding gene

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10.1124/DMD.114.057620

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