(Q24293608)

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Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase

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scholarly article

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Europe PubMed Central

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28 December 2019

Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15152005%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

endoplasmic reticulum

0 references

0 references

hydroxysteroid 11-beta dehydrogenase 1

1 reference

GOA release 2020-03-11

Arylacetamide deacetylase

1 reference

GOA release 2020-03-11

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

1 reference

GOA release 2020-03-11

Atanas G. Atanasov

2

1 reference

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28 December 2019

author name string

Christoph Frick

1

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28 December 2019

Peter Arnold

3

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28 December 2019

Juris Ozols

4

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28 December 2019

Alex Odermatt

5

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28 December 2019

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publication date

19 May 2004

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28 December 2019

Journal of Biological Chemistry

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28 December 2019

279

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28 December 2019

30

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28 December 2019

31131-31138

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28 December 2019

11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

1 reference

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21 January 2018

A transgenic model of visceral obesity and the metabolic syndrome

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Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.

1 reference

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21 January 2018

Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains

1 reference

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21 January 2018

Is 11beta-hydroxysteroid dehydrogenase type 1 a good therapeutic target for blockade of glucocorticoid actions?

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11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

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21 January 2018

Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme

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21 January 2018

Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages

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21 January 2018

Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?

1 reference

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21 January 2018

Purification, characterization and NNK carbonyl reductase activities of 11beta-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen

1 reference

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21 January 2018

Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1.

1 reference

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21 January 2018

11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess

1 reference

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21 January 2018

The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313666200

21 January 2018

Functional expression, characterization, and purification of the catalytic domain of human 11-beta -hydroxysteroid dehydrogenase type 1.

1 reference

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21 January 2018

The critical role of the N-terminus of 11beta-hydroxysteroid dehydrogenase type 1, as being encoded by exon 1, for enzyme stabilization and activity

1 reference

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21 January 2018

Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase

1 reference

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21 January 2018

The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2.

1 reference

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21 January 2018

Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation

1 reference

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21 January 2018

A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity

1 reference

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21 January 2018

Cortisol is transported by the multidrug resistance gene product P-glycoprotein

1 reference

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21 January 2018

Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule

1 reference

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21 January 2018

Transmembrane protein insertion orientation in yeast depends on the charge difference across transmembrane segments, their total hydrophobicity, and its distribution.

1 reference

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21 January 2018

Glutamate-115 renders specificity of human 11beta-hydroxysteroid dehydrogenase type 2 for the cofactor NAD+.

1 reference

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21 January 2018

Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the lumen of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313666200

21 January 2018

Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313666200

21 January 2018

Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers

1 reference

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21 January 2018

Intracellular cholesterol and phospholipid trafficking: comparable mechanisms in macrophages and neuronal cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313666200

21 January 2018

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1 reference

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21 January 2018

Transport-Dependent Proteolysis of SREBP

1 reference

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21 January 2018

Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313666200

21 January 2018

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313666200

21 January 2018

11 Beta-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages

1 reference

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21 January 2018

Human 11beta-hydroxysteroid dehydrogenase type 1 is enzymatically active in its nonglycosylated form

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Oxysterols and atherosclerosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313666200

7 January 2021

based on heuristic

inferred from DOI database lookup

Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313666200

7 January 2021

based on heuristic

inferred from DOI database lookup

Metyrapone is a competitive inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313666200

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional characterization of the human 11 beta-hydroxysteroid dehydrogenase 1B (11 beta-HSD 1B) variant

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Oxysterols: modulators of cholesterol metabolism and other processes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M313666200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15152005%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15152005%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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