(Q24303862)

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Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kappaB p65 trans activation plays a novel role

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Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kappaB p65 trans activation plays a novel role (English)

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lipopolysaccharide

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Rac family small GTPase 1

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GOA release 2020-03-11

negative regulation of interleukin-23 production

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GOA release 2020-03-11

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based on heuristic

inferred from title

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author name string

Mitsuyoshi Utsugi

1

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Kunio Dobashi

2

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Tamotsu Ishizuka

3

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Tadayoshi Kawata

4

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Takeshi Hisada

5

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Yasuo Shimizu

6

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Akihiro Ono

7

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Masatomo Mori

8

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language of work or name

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publication date

1 October 2006

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Journal of Immunology

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177

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7

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4550-7

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The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells

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Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells

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Regulation of interleukin-12 production in antigen-presenting cells

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

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based on heuristic

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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Dendritic cell development and survival require distinct NF-kappaB subunits

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based on heuristic

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

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Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell lines

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Dendritic cells and the control of immunity

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based on heuristic

inferred from DOI database lookup

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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based on heuristic

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PI3K-mediated negative feedback regulation of IL-12 production in DCs

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Interleukin-12 and the regulation of innate resistance and adaptive immunity

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based on heuristic

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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

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based on heuristic

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Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

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based on heuristic

inferred from DOI database lookup

CREB-binding protein/p300 are transcriptional coactivators of p65

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

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based on heuristic

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IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

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based on heuristic

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Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

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based on heuristic

inferred from DOI database lookup

Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

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Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression

1 reference

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The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells

1 reference

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based on heuristic

inferred from DOI database lookup

Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

1 reference

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based on heuristic

inferred from DOI database lookup

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

7 January 2021

based on heuristic

inferred from DOI database lookup

Rho GTPases and signaling networks

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

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based on heuristic

inferred from DOI database lookup

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

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based on heuristic

inferred from DOI database lookup

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

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based on heuristic

inferred from DOI database lookup

Toll-like receptors

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Contribution of small GTPase Rho and its target protein rock in a murine model of lung fibrosis

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Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

1 reference

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based on heuristic

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Increased production of pro-inflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL-1 and CD40 ligand

1 reference

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based on heuristic

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Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1-type cytokines and chemokines in human monocyte-derived dendritic cells.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

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based on heuristic

inferred from DOI database lookup

Rho-family GTPases: it's not only Rac and Rho (and I like it).

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.177.7.4550

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based on heuristic

inferred from DOI database lookup

Regulation of virus-induced IL-12 and IL-23 expression in human macrophages

1 reference

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c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production

1 reference

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Identifiers

10.4049/JIMMUNOL.177.7.4550

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