(Q24306819)

English

Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart

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scholarly article

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Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart (English)

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heart arrhythmia

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GTP-binding protein RAD

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GOA release 2020-03-11

author name string

Hirotaka Yada

1

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Mitsushige Murata

2

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Kouji Shimoda

3

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Shinsuke Yuasa

4

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Haruko Kawaguchi

5

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Masaki Ieda

6

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Takeshi Adachi

7

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Mitsuru Murata

8

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Satoshi Ogawa

9

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Keiichi Fukuda

10

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language of work or name

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publication date

6 July 2007

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Circulation Research

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101

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1

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69-77

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Nuclear sequestration of beta-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

The RGK family: a regulatory tail of small GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Two types of calcium channels in guinea pig ventricular myocytes

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of the complex between Ca2+ channel beta-subunit and the Rem GTPase

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Response of the QT interval to mental and physical stress in types LQT1 and LQT2 of the long QT syndrome

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Physiological role of ROCKs in the cardiovascular system

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface density

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Diabetic cardiomyopathy: electromechanical cellular alterations

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice

1 reference

https://api.crossref.org/works/10.1161%2FCIRCRESAHA.106.146399

7 January 2021

based on heuristic

inferred from DOI database lookup

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