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Imbalances in p97 co-factor interactions in human proteinopathy
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scholarly article
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title
Imbalances in p97 co-factor interactions in human proteinopathy
(English)
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author name string
Vanesa Fernández-Sáiz
series ordinal
1
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Alexander Buchberger
series ordinal
2
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language of work or name
English
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publication date
June 2010
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published in
EMBO Reports
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volume
11
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issue
6
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page(s)
479-85
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cites work
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An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
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A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways
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Structure of the AAA ATPase p97
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PubMed Central
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Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone
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19 March 2017
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
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Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation
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UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97
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Conformational changes in the AAA ATPase p97-p47 adaptor complex
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Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation
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Nucleotide dependent motion and mechanism of action of p97/VCP
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Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
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Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
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Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia
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27 September 2017
UBXD1 binds p97 through two independent binding sites.
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VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: review of a unique disorder
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27 September 2017
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease
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27 September 2017
Role(s) of Cdc48/p97 in mitosis.
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27 September 2017
Insights into adaptor binding to the AAA protein p97.
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27 September 2017
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy
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27 September 2017
Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders
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27 September 2017
Molecular clearance of ataxin-3 is regulated by a mammalian E4
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27 September 2017
Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins
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30 May 2018
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
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30 May 2018
Pathological consequences of VCP mutations on human striated muscle.
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30 May 2018
D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892324
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29 November 2018
Vacuole-creating protein in neurodegenerative diseases in humans.
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PubMed Central
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29 November 2018
VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration
1 reference
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PubMed Central
reference URL
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retrieved
29 November 2018
Identifiers
DOI
10.1038/EMBOR.2010.49
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1382790
OpenCitations bibliographic resource ID
1382790
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1382790
PMCID
2892324
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1382790
PubMed ID
20414249
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1382790
ResearchGate publication ID
43299780
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