(Q24312937)

English

Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone

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Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone (English)

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transmembrane protein

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cystic fibrosis

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molecular chaperones

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Cystic fibrosis transmembrane conductance regulator

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GOA release 2020-03-11

author name string

Toby S Scott-Ward

1

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Margarida D Amaral

2

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language of work or name

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publication date

December 2009

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276

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7097-109

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23

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

CFTR and chaperones: processing and degradation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

From the cradle to the grave: molecular chaperones that may choose between folding and degradation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Biological heterogeneity of the peptide-binding motif of the 70-kDa heat shock protein by surface plasmon resonance analysis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Hsc70-binding peptides selected from a phage display peptide library that resemble organellar targeting sequences

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Kinetics of peptide binding to the bovine 70 kDa heat shock cognate protein, a molecular chaperone

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

The molecular chaperone Hsc70 assists the in vitro folding of the N-terminal nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Alteration of the cystic fibrosis transmembrane conductance regulator folding pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Surface plasmon resonance and its use in biomolecular interaction analysis (BIA).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Side chain and backbone contributions of Phe508 to CFTR folding

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

A general method for greatly improving the affinity of antibodies by using combinatorial libraries

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Correctors promote folding of the CFTR in the endoplasmic reticulum.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

70-kDa heat shock proteins: specific interactions with HLA-DR molecules and their peptide fragments

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Analysis of molecular interactions in heat-induced aggregation of a non-inhibitory serpin ovalbumin using a molecular chaperone

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Annexin V is directly involved in cystic fibrosis transmembrane conductance regulator's chloride channel function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Mutations in the nucleotide binding domain 1 signature motif region rescue processing and functional defects of cystic fibrosis transmembrane conductance regulator delta f508.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Processing and function of CFTR-DeltaF508 are species-dependent

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

A recombinant peptide model of the first nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator: comparison of wild-type and delta F508 mutant forms

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Intrinsic anion channel activity of the recombinant first nucleotide binding fold domain of the cystic fibrosis transmembrane regulator protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Solubilizing Mutations Used to Crystallize One CFTR Domain Attenuate the Trafficking and Channel Defects Caused by the Major Cystic Fibrosis Mutation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Modelling the restoration of wild-type dynamic behaviour in ΔF508-CFTR NBD1 by 8-cyclopentyl-1,3-dipropylxanthine

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

21 January 2018

Conformational lability of two molecular chaperones Hsc70 and gp96: effects of pH and temperature

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Spectroscopic and thermodynamic measurements of nucleotide-induced changes in the human 70-kDa heat shock cognate protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

7 January 2021

based on heuristic

inferred from DOI database lookup

DeltaF508 mutation increases conformational flexibility of CFTR protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Localization and suppression of a kinetic defect in cystic fibrosis transmembrane conductance regulator folding

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07421.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1111/J.1742-4658.2009.07421.X

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