(Q24321858)

protein dimerization activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Sirano Dhe-Paganon

5

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author name string

Young-In Chi

1

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J Daniel Frantz

2

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Byung-Chul Oh

3

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Lone Hansen

4

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Steven E Shoelson

MODY associated with two novel hepatocyte nuclear factor-1alpha loss-of-function mutations (P112L and Q466X)

6

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language of work or name

English

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publication date

November 2002

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published in

Molecular Cell

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volume

10

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issue

5

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page(s)

1129-37

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cites work

1 reference

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7 January 2021

Putative nuclear localization signals (NLS) in protein transcription factors

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7 January 2021

Mutation screening in 18 Caucasian families suggest the existence of other MODY genes

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7 January 2021

Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters

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7 January 2021

Missense mutations of human homeoboxes: A review

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7 January 2021

Regulation of a transcription factor network required for differentiation and metabolism

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7 January 2021

Hepatocyte nuclear factor 1 alpha (HNF-1 alpha) mutations in maturity-onset diabetes of the young

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7 January 2021

Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene

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7 January 2021

Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

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7 January 2021

Mutations in the Hepatocyte Nuclear Factor-1 Gene Are a Common Cause of Maturity-Onset Diabetes of the Young in the U.K

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7 January 2021

Genetic determinants of type 2 diabetes

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7 January 2021

Novel mutations and a mutational hotspot in the MODY3 gene

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7 January 2021

Novel MODY3 Mutations in the Hepatocyte Nuclear Factor-1 Gene: Evidence for a Hyperexcitability of Pancreatic -cells to Intravenous Secretagogues in a Glucose-Tolerant Carrier of a P447L Mutation

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7 January 2021

Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

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7 January 2021

Youth-onset type 2 diabetes (Y2DM) associated with HNF1A S319 in aboriginal Canadians

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7 January 2021

Diabetes-associated mutations in a beta-cell transcription factor destabilize an antiparallel "mini-zipper" in a dimerization interface

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7 January 2021

Mutations in the hepatocyte nuclear factor-1alpha/MODY3 gene in Japanese subjects with early- and late-onset NIDDM.

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7 January 2021

Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4.

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7 January 2021

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions

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7 January 2021

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules

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7 January 2021

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

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7 January 2021

Initial sequencing and analysis of the human genome

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7 January 2021

High frequency of mutations in MODY and mitochondrial genes in Scandinavian patients with familial early-onset diabetes

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7 January 2021

Mutations in the hepatocyte nuclear factor-1α gene in Caucasian families originally classified as having Type I diabetes

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7 January 2021

The dimerization domain of HNF-1alpha: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus

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7 January 2021

Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.

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7 January 2021

A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1.

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7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

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7 January 2021

Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha

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7 January 2021

High-resolution structure of the HNF-1alpha dimerization domain

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7 January 2021

The NMR solution structure of the non-classical homeodomain from the rat liver LFB1/HNF1 transcription factor

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7 January 2021

Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification

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7 January 2021

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

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7 January 2021

Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome

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7 January 2021

A prevalent amino acid polymorphism at codon 98 in the hepatocyte nuclear factor-1alpha gene is associated with reduced serum C-peptide and insulin responses to an oral glucose challenge

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7 January 2021

Anatomy of a homeoprotein revealed by the analysis of human MODY3 mutations

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7 January 2021

The Sequence of the Human Genome

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7 January 2021

Homeodomain interactions

1 reference

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7 January 2021

Identification of mutations in the hepatocyte nuclear factor (HNF)-1 alpha gene in Japanese subjects with IDDM

1 reference

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7 January 2021

Identification of mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with early-onset NIDDM and functional analysis of the mutant proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900704-9

7 January 2021

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900704-9

7 January 2021

Structure/function studies of hepatocyte nuclear factor-1alpha, a diabetes-associated transcription factor

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7 January 2021

Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization

1 reference

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7 January 2021

10.1016/S1097-2765(02)00704-9

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12453420

1 reference

Consolidated OpenCitations Corpus – April 2017