(Q24324618)

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PKHD1 gene silencing may cause cell abnormal proliferation through modulation of intracellular calcium in autosomal recessive polycystic kidney disease

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PKHD1 gene silencing may cause cell abnormal proliferation through modulation of intracellular calcium in autosomal recessive polycystic kidney disease (English)

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autosomal recessive polycystic kidney

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PKHD1 ciliary IPT domain containing fibrocystin/polyductin

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GOA release 2020-03-11

regulation of ERK1 and ERK2 cascade

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GOA release 2020-03-11

author name string

Jiyun Yang

1

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Sizhong Zhang

2

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Qin Zhou

3

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Hong Guo

4

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Ke Zhang

5

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Rong Zheng

6

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Cuiying Xiao

7

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language of work or name

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publication date

31 July 2007

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40

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4

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467-74

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PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD).

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A novel gene encoding a TIG multiple domain protein is a positional candidate for autosomal recessive polycystic kidney disease

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https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

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Autosomal recessive polycystic kidney disease

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https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

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based on heuristic

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Bending the MDCK cell primary cilium increases intracellular calcium

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

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Removal of the MDCK cell primary cilium abolishes flow sensing

1 reference

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Autosomal recessive polycystic kidney disease: long-term outcome of neonatal survivors

1 reference

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Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling

1 reference

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7 January 2021

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PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation

1 reference

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Role of ERK1/2 signaling during EGF-induced inhibition of palatal fusion

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

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Mechanisms of Ca(2+)-dependent transcription

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Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

1 reference

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Rational siRNA design for RNA interference

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Mapping of the gene for autosomal recessive polycystic kidney disease (ARPKD) to chromosome 6p21-cen

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

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The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

1 reference

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7 January 2021

based on heuristic

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SET-induced calcium signaling and MAPK/ERK pathway activation mediate dendritic cell-like differentiation of U937 cells

1 reference

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Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

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Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability

1 reference

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PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

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The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade.

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

inferred from DOI database lookup

PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

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Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

inferred from DOI database lookup

Autosomal recessive polycystic kidney disease in adulthood

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

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Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

inferred from DOI database lookup

EGF-related growth factors in the pathogenesis of murine ARPKD.

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD)

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

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Autosomal recessive polycystic kidney disease in 115 children: clinical presentation, course and influence of gender. Arbeitsgemeinschaft für Pädiatrische, Nephrologie

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

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A role for ERK1/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

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Abnormal EGF-dependent regulation of sodium absorption in ARPKD collecting duct cells

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

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Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

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H2O2-induced transactivation of EGF receptor requires Src and mediates ERK1/2, but not Akt, activation in renal cells

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells

1 reference

https://api.crossref.org/works/10.5483%2FBMBREP.2007.40.4.467

7 January 2021

based on heuristic

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Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease

1 reference

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The BDNF gene: exemplifying complexity in Ca2+ -dependent gene expression.

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Prevalence of abnormal urinary albumin excretion rate in hypertensive patients with impaired fasting glucose and its association with cardiovascular disease

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10.5483/BMBREP.2007.40.4.467

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