(Q24528162)

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Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474

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scholarly article

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Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474 (English)

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author name string

B Gerlitz

1

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T Hassell

2

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C J Vlahos

3

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J F Parkinson

4

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N U Bang

5

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B W Grinnell

6

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language of work or name

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publication date

1 October 1993

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Biochemical Journal

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295 ( Pt 1)

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131-40

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Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues

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Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA

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Structure of the glycosaminoglycan domain in the type IX collagen-proteoglycan

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24 March 2017

Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene

1 reference

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24 March 2017

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation

1 reference

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24 March 2017

Multiple domains of the large fibroblast proteoglycan, versican

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24 March 2017

A comprehensive set of sequence analysis programs for the VAX

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24 March 2017

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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24 March 2017

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

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24 March 2017

The active site of the thrombin-thrombomodulin complex. A fluorescence energy transfer measurement of its distance above the membrane surface

1 reference

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24 March 2017

Expression cloning and characterization of the TGF-beta type III receptor

1 reference

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24 March 2017

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system

1 reference

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24 March 2017

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

24 March 2017

The roles of protein C and thrombomodulin in the regulation of blood coagulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

24 March 2017

Preparation and properties of bovine factor VIII (antihemophilic factor).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Cytochemical localization of terminal N-acetyl-D-galactosamine residues in cellular compartments of intestinal goblet cells: implications for the topology of O-glycosylation

1 reference

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27 September 2017

Binding of transferrin to the core protein of fibroblast proteoheparan sulfate

1 reference

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27 September 2017

Identification and synthesis of a recognition signal for the attachment of glycosaminoglycans to proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Functional domains of rabbit thrombomodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

A variant enhancer/regulatory region from a cloned human prototype BK virus genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Stable expression of a secretable deletion mutant of recombinant human thrombomodulin in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Structure and function of thrombomodulin: a natural anticoagulant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Characterization of rat transferrin receptor cDNA: the regulation of transferrin receptor mRNA in testes and in Sertoli cells in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

27 September 2017

Proteoglycans: structures and interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

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1 reference

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27 September 2017

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine

1 reference

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27 September 2017

Anticoagulant properties of bovine plasma protein C following activation by thrombin

1 reference

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27 September 2017

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells

1 reference

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27 September 2017

Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

30 May 2018

Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones.

1 reference

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30 May 2018

Proteolytic formation and properties of functional domains of thrombomodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

30 May 2018

Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors

1 reference

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1 reference

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30 May 2018

Further localization of binding sites for thrombin and protein C in human thrombomodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

30 May 2018

Presence and function of chondroitin-4-sulfate on recombinant human soluble thrombomodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

30 May 2018

Amino acid distributions around O-linked glycosylation sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

30 May 2018

Recombinant human thrombomodulin. Regulation of cofactor activity and anticoagulant function by a glycosaminoglycan side chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

30 May 2018

Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

30 May 2018

Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

30 May 2018

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

19 June 2018

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1 reference

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29 November 2018

Xylosylation and glucuronosylation reactions in rat liver Golgi apparatus and endoplasmic reticulum

1 reference

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29 November 2018

Chick cartilage chondroitin sulfate proteoglycan core protein. I. Generation and characterization of peptides and specificity for glycosaminoglycan attachment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134829

29 November 2018

Isolation and characterization of the glycosaminoglycan component of rabbit thrombomodulin proteoglycan

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of O-linked oligosaccharides on proteoglycans by chondrocytes from the swarm rat chondrosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombomodulin blocks the ability of thrombin to activate platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular localization of the synthesis and glycosylation of chondroitin sulfate proteoglycan core protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin decreases glycosaminoglycans content of endothelial cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of thrombin on the production of glycosaminoglycans by cultured endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between post-translational glycosylation and anticoagulant function of secretable recombinant mutants of human thrombomodulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of activation of antihemophilic globulin and proaccelerin by traces of thrombin in the generation of intrinsic prothrombinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of thrombin to thrombomodulin accelerates inhibition of the enzyme by antithrombin III. Evidence for a heparin-independent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of thrombomodulin on the cleavage of fibrinogen and fibrinogen fragments by thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between anticoagulant activities and polyanionic properties of rabbit thrombomodulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The last three consecutive epidermal growth factor-like structures of human thrombomodulin comprise the minimum functional domain for protein C-activating cofactor activity and anticoagulant activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain structure of the endothelial cell receptor thrombomodulin as deduced from modulation of its anticoagulant functions. Evidence for a glycosaminoglycan-dependent secondary binding site for thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of N- and O-linked glycopeptides in oviduct membrane preparations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal aspects of the N- and O-glycosylation of human chorionic gonadotropin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of human coagulation factor V by activated protein C

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased thrombin affinity of cell-surface thrombomodulin following treatment of cultured endothelial cells with beta-D-xyloside

1 reference

https://pubmed.ncbi.nlm.nih.gov/8216207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ2950131

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