(Q24550608)

English

Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities

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scholarly article

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Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities (English)

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inferred from title

author name string

K E Zhang

1

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E Wu

2

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A K Patick

3

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B Kerr

4

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M Zorbas

5

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A Lankford

6

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T Kobayashi

7

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Y Maeda

8

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B Shetty

9

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S Webber

10

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language of work or name

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publication date

April 2001

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Antimicrobial Agents and Chemotherapy

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45

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4

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1086-93

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Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease

1 reference

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Safety, pharmacokinetics, and antiretroviral activity of the potent, specific human immunodeficiency virus protease inhibitor nelfinavir: results of a phase I/II trial and extended follow-up in patients infected with human immunodeficiency virus

1 reference

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In vitro effect of alpha1-acid glycoprotein on the anti-human immunodeficiency virus (HIV) activity of the protease inhibitor CGP 61755: a comparative study with other relevant HIV protease inhibitors

1 reference

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Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations

1 reference

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27 September 2017

Saquinavir: an HIV proteinase inhibitor

1 reference

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Indinavir: a pharmacologic and clinical review of a new HIV protease inhibitor.

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Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection

1 reference

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1 reference

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30 May 2018

HIV-protease inhibitors

1 reference

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Saquinavir. Clinical pharmacology and efficacy

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Antiretroviral therapy for HIV infection in 1997. Updated recommendations of the International AIDS Society-USA panel

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Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism

1 reference

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Clinical implications of genetic polymorphisms and drug interactions mediated by cytochrome P-450 enzymes.

1 reference

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28 November 2018

Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. International AIDS Society--USA Panel.

1 reference

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A preliminary evaluation of nelfinavir mesylate, an inhibitor of human immunodeficiency virus (HIV)-1 protease, to treat HIV infection

1 reference

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Antiretroviral therapy for HIV infection: promises and problems

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Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans

1 reference

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Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatographic method for the determination of nelfinavir, a novel HIV-1 protease inhibitor, in human plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11257019

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiretroviral therapy for HIV infection in 1998: updated recommendations of the International AIDS Society-USA Panel

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Development of HIV protease inhibitors: a survey

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.45.4.1086-1093.2001

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