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Two distinct mechanisms for negative regulation of the Wee1 protein kinase
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Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
title
Two distinct mechanisms for negative regulation of the Wee1 protein kinase
(English)
1 reference
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
author name string
Z Tang
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
T R Coleman
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
W G Dunphy
series ordinal
3
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stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
language of work or name
English
0 references
publication date
1 September 1993
1 reference
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
published in
The EMBO Journal
1 reference
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
volume
12
1 reference
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
issue
9
1 reference
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
page(s)
3427-3436
1 reference
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
cites work
Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15
1 reference
stated in
PubMed Central
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24 March 2017
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
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24 March 2017
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
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24 March 2017
Conservation of mitotic controls in fission and budding yeasts
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24 March 2017
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2
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PubMed Central
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7 April 2017
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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7 April 2017
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
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PubMed Central
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7 April 2017
Universal control mechanism regulating onset of M-phase
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PubMed Central
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7 April 2017
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
Induction of nuclear envelope breakdown, chromosome condensation, and spindle formation in cell-free extracts
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
Cyclin synthesis drives the early embryonic cell cycle
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
Driving the cell cycle: M phase kinase, its partners, and substrates
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PubMed Central
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27 September 2017
Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
Genetic and molecular analysis of cdr1/nim1 in Schizosaccharomyces pombe
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
cdc2 phosphorylation is required for its interaction with cyclin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
27 September 2017
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
27 September 2017
Activation of human cyclin-dependent kinases in vitro
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
Role of phosphorylation in p34cdc2 activation: identification of an activating kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
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27 September 2017
Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
27 September 2017
Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
27 September 2017
p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
27 September 2017
cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
27 September 2017
Genetic control of cell size at cell division in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
27 September 2017
The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Cyclin activation of p34cdc2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Cyanogen bromide cleavage and proteolytic peptide mapping of proteins immobilized to membranes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
INH, a negative regulator of MPF, is a form of protein phosphatase 2A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Cloning and Characterization of Xenopus cdc2, a Component of MPF
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
The cdc25 protein contains an intrinsic phosphatase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Regulation of the cdc25 protein during the cell cycle in Xenopus extracts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
30 May 2018
Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413619
retrieved
28 November 2018
Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/7504624
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/7504624
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1002/J.1460-2075.1993.TB06017.X
1 reference
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
OpenCitations bibliographic resource ID
3205372
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3205372
PMCID
413619
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3205372
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
PubMed ID
7504624
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3205372
stated in
Europe PubMed Central
PMCID
413619
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7504624%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
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