(Q24619854)

2

0 references

Ryan Hutchinson

3

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Zephania W Kwong

4

0 references

Jihong Yang

5

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Xiangdan Wang

6

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Zhenling Yao

7

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Alavattam Sreedhara

8

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Tony Cano

9

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Devin Tesar

10

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Ihsan Nijem

11

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David E Allison

12

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Pin Yee Wong

13

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Yung-Hsiang Kao

14

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Cynthia Quan

15

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Amita Joshi

16

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Reed J Harris

17

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Paul Motchnik

18

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language of work or name

English

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publication date

2010

1 reference

Charge density-dependent strength of hydration and biological structure

published in

Monoclonal Antibodies

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volume

2

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issue

6

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page(s)

613-24

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Improving the efficacy of antibody-based cancer therapies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Microlymphatics and lymph flow

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Subcutaneous drug delivery and the role of the lymphatics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Pharmacokinetic, pharmacodynamic and immunogenicity comparability assessment strategies for monoclonal antibodies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Surface charge: a key determinant of protein localization and function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Analysis of charge heterogeneities in mAbs using imaged CE.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Structural and functional characterization of disulfide isoforms of the human IgG2 subclass

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Human IgG2 antibodies display disulfide-mediated structural isoforms

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

FcRn: the neonatal Fc receptor comes of age.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Analysis of lysine clipping of a humanized Lewis-Y specific IgG antibody and its relation to Fc-mediated effector function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Antibody structure, instability, and formulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Characterizing biological products and assessing comparability following manufacturing changes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Pharmacokinetic aspects of biotechnology products

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Factors affecting pharmacokinetics of monoclonal antibodies: A review article

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Monoclonal antibody radiopharmaceuticals: cationization, pegylation, radiometal chelation, pharmacokinetics, and tumor imaging

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

X-ray crystallographic studies of IgG-Fc gamma receptor interactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Pressure effects on intra- and intermolecular interactions within proteins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Improving monoclonal antibody pharmacokinetics via chemical modification.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Effect of C2-associated carbohydrate structure on Ig effector function: studies with chimeric mouse-human IgG1 antibodies in glycosylation mutants of Chinese hamster ovary cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

General structure and heterogeneity of immunoglobulins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Monoclonal antibody modification with chelate-linked high-molecular-weight polymers: major increases in polyvalent cation binding without loss of antigen binding

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Exploration of novel strategies to enhance monoclonal antibodies targeting

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Improved tumor localization and radioimaging with chemically modified monoclonal antibodies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Developmental regulation of sialic acid modifications in rat and human colon.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Effect of isoelectric point on biodistribution and inflammation: imaging with indium-111-labelled IgG.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Free sulfhydryl in recombinant monoclonal antibodies

30 May 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Full-length antibodies on display.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Flexibility--the guiding principle for antibody manufacturing

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Influence of pH, buffer species, and storage temperature on physicochemical stability of a humanized monoclonal antibody LA298.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Cation exchange-HPLC and mass spectrometry reveal C-terminal amidation of an IgG1 heavy chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Reduced elimination of IgG antibodies by engineering the variable region.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Pharmacokinetic characteristics and biodistribution of radioiodinated chimeric TNT-1, -2, and -3 monoclonal antibodies after chemical modification with biotin

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.6.13333

Identification of multiple sources of charge heterogeneity in a recombinant antibody.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Cationized hyperimmune immunoglobulins: pharmacokinetics, toxicity evaluation and treatment of human immunodeficiency virus-infected human-peripheral blood lymphocytes-severe combined immune deficiency mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3011216

Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

28 November 2018

1 reference

12 December 2020

Comparison of methionine oxidation in thermal stability and chemically stressed samples of a fully human monoclonal antibody

1 reference

12 December 2020

Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point

1 reference

12 December 2020

Determination of the origin of charge heterogeneity in a murine monoclonal antibody

1 reference

12 December 2020

Analysis of recombinant monoclonal antibody isoforms by electrospray ionization mass spectrometry as a strategy for streamlining characterization of recombinant monoclonal antibody charge heterogeneity

1 reference

12 December 2020

Pharmacokinetics and organ distribution of cationized colchicine-specific IgG and Fab fragments in rat

1 reference

12 December 2020

Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors

1 reference

12 December 2020

Effects of chemical modification of antibodies on their clearance from the circulation. Addition of simple aliphatic compounds by reductive alkylation and carbodiimide-promoted amide formation

1 reference

12 December 2020

Modification of antibody isoelectric point affects biodistribution of 111-indium-labeled antibody

1 reference

12 December 2020

Peak identification in capillary isoelectric focusing using the concept of relative peak position as determined by two isoelectric point markers

1 reference

12 December 2020

Identifiers

DOI

10.4161/MABS.2.6.13333

1 reference

1 reference

1 reference

PubMed publication ID

20818176

1 reference