(Q24629725)

English

Crystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targets

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scholarly article

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28 December 2019

Crystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targets (English)

1 reference

Europe PubMed Central

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28 December 2019

crystal structure

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protein structure

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Escherichia coli

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2

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28 December 2019

Enoch P Baldwin

4

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28 December 2019

author name string

James A Endrizzi

1

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28 December 2019

Paul M Anderson

3

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28 December 2019

language of work or name

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publication date

1 June 2004

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28 December 2019

number of pages

17

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based on heuristic

inferred from page(s)

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28 December 2019

43

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28 December 2019

21

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28 December 2019

6447-6463

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Europe PubMed Central

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28 December 2019

Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness

1 reference

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7 April 2017

The COG database: new developments in phylogenetic classification of proteins from complete genomes

1 reference

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7 April 2017

Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells

1 reference

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7 April 2017

Structural role for a conserved region in the CTP synthetase glutamine amide transfer domain

1 reference

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7 April 2017

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1 reference

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7 April 2017

From The Cover: Automated protein crystal structure determination using ELVES

1 reference

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Toward understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerolphosphate synthase: crystal structures of a ternary complex and the free enzyme

1 reference

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Ligand-induced structural changes in adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum

1 reference

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7 April 2017

Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A

1 reference

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7 April 2017

The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway

1 reference

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7 April 2017

Structure of dethiobiotin synthetase at 0.97 A resolution

1 reference

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7 April 2017

The structure of elongation factor G in complex with GDP: conformational flexibility and nucleotide exchange

1 reference

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7 April 2017

The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families

1 reference

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7 April 2017

Mechanistic implications and family relationships from the structure of dethiobiotin synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Raster3D: photorealistic molecular graphics

1 reference

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7 April 2017

SHELXL: high-resolution refinement

1 reference

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7 April 2017

The CCP4 suite: programs for protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Rapid automated molecular replacement by evolutionary search

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Protein structure comparison by alignment of distance matrices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Molecular cloning and characterization of the Plasmodium falciparum cytidine triphosphate synthetase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Purification and characterization of CTP synthetase, the product of the URA7 gene in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Potentiation of the anti-HIV activity of zalcitabine and lamivudine by a CTP synthase inhibitor, 3-deazauridine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Resistance to cytosine arabinoside in acute leukemia: the significance of mutations in CTP synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

CTP synthetase from Escherichia coli: an improved purification procedure and characterization of hysteretic and enzyme concentration effects on kinetic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

The Subunit Structure and Subunit Interactions of Cytidine Triphosphate Synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Cytidine triphosphate synthetase. Covalent intermediates and mechanisms of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Mechanistic investigations of Escherichia coli cytidine-5'-triphosphate synthetase. Detection of an intermediate by positional isotope exchange experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Investigation of the mechanism of CTP synthetase using rapid quench and isotope partitioning methods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Classification and evolution of P-loop GTPases and related ATPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Assessment of phase accuracy by cross validation: the free R value. Methods and applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

7 April 2017

Enzymes with molecular tunnels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Identification of novel cellular targets in biliary tract cancers using global gene expression technology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Cyclopentenyl cytosine primes SK-N-BE(2)c neuroblastoma cells for cytarabine toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Cyclopentenyl cytosine induces apoptosis and secondary necrosis in a T-lymphoblastic leukemic cell-line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Interactions among pathways for phosphatidylcholine metabolism, CTP synthesis and secretion through the Golgi apparatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

A single point mutation in CTP synthetase of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Pyrimidine metabolism by intracellular Chlamydia psittaci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Molecular approaches for the treatment of hemorrhagic fever virus infections.

1 reference

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27 September 2017

Cloning and expression of the Chlamydia trachomatis gene for CTP synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Gross quaternary changes in aspartate carbamoyltransferase are induced by the binding of N-(phosphonacetyl)-L-aspartate: A 3.5-A resolution study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Regulation of eukaryotic phospholipid metabolism 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

12 Cystidine triphosphate synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Increased CTP synthetase activity in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

The mechanism of action of 3-deazauridine in tumor cells sensitive and resistant to arabinosylcytosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

27 September 2017

Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

30 May 2018

Cloning and verification of the Lactococcus lactis pyrG gene and characterization of the gene product, CTP synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

30 May 2018

Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

30 May 2018

Mechanism of resistance to cyclopentenyl cytosine (CPE-C) in Molt-4 lymphoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

30 May 2018

Resistance to cyclopentenylcytosine in murine leukemia L1210 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

30 May 2018

Half-of-the-sites reactivity and conformational states of cytidine triphosphate synthetase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

30 May 2018

Mammalian mutants genetically altered in CTP synthetase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

30 May 2018

Purine and pyrimidine metabolism of normal and leukemic lymphocytes

1 reference

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30 May 2018

Comparison of pyrimidine nucleotide synthetic enzymes involved in 5-fluorouracil metabolism between human adenocarcinomas and squamous cell carcinomas

1 reference

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30 May 2018

CTP synthetase of bovine calf liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

30 May 2018

Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells

1 reference

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28 November 2018

Limited proteolysis of Escherichia coli cytidine 5′‐triphosphate synthase. Identification of residues required for CTP formation and GTP‐dependent activation of glutamine hydrolysis

1 reference

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28 November 2018

Phosphorylation of Saccharomyces cerevisiae CTP Synthetase at Ser424 by Protein Kinases A and C Regulates Phosphatidylcholine Synthesis by the CDP-choline Pathway

1 reference

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28 November 2018

Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae

1 reference

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28 November 2018

Expression, purification and preliminary X-ray characterization of CTP synthetase from Thermus thermophilus HB8.

1 reference

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28 November 2018

Thr-431 and Arg-433 are part of a conserved sequence motif of the glutamine amidotransferase domain of CTP synthases and are involved in GTP activation of the Lactococcus lactis enzyme.

1 reference

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28 November 2018

Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis. The role of the allosteric activator GTP incoupling between glutamine hydrolysis and CTP synthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

28 November 2018

Nucleotide-dependent tetramerization of CTP synthetase from Saccharomyces cerevisiae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

28 November 2018

Repression of cytidine triphosphate synthetase in Salmonella typhimurium by pyrimidines during uridine nucleotide depletion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891762

28 November 2018

Cyclopentenyluridine and cyclopentenylcytidine analogs as inhibitors of uridine-cytidine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

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inferred from PubMed ID database lookup

Role of an allosteric effector. Guanosine triphosphate activation in cytosine triphosphate synthetase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical pharmacology of acivicin in rat hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of CTP synthetase from Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased activity of cytidine Triphosphate synthetase in pediatric acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the antitumor activity and biochemical actions of cyclopentenyl cytosine against human colon carcinoma HT-29 in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytidine triphosphate synthetase activity in lymphoproliferative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytidine triphosphate synthetase of Escherichia coli B. I. Purification and kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a novel dUTP-dependent activity of CTP synthetase from Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CTP synthetase from Ehrlich ascites tumor cells. Subunit stoichiometry and regulation of activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of subunit dissociation constants in native and inactivated CTP synthetase by sedimentation equilibrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNT refinement package

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of glutamine in the biosynthesis of cytidine nucleotides in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-induced dimer-to-tetramer transformation in cytosine triphosphate synthetase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CTP synthetase and enzymes of pyrimidine ribonucleotide metabolism in Giardia intestinalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ regulation of mammalian CTP synthetase by allosteric inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15157079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI0496945

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15157079%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15157079%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15157079%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

ResearchGate publication ID

0 references

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