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Ultrasensitivity in the Regulation of Cdc25C by Cdk1
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title
Ultrasensitivity in the Regulation of Cdc25C by Cdk1
(English)
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main subject
cell biology
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author name string
Nicole B Trunnell
series ordinal
1
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Andy C Poon
series ordinal
2
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Sun Young Kim
series ordinal
3
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James E Ferrell
series ordinal
4
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language of work or name
English
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publication date
4 February 2011
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published in
Molecular Cell
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volume
41
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issue
3
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page(s)
263-74
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cites work
Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases
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Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
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Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts
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Plk1 promotes nuclear translocation of human Cdc25C during prophase
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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
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The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins
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7 April 2017
Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
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7 April 2017
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex
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7 April 2017
Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15
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Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
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Cell cycle regulation of human WEE1
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7 April 2017
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein
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7 April 2017
Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A
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7 April 2017
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL
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7 April 2017
A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway
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7 April 2017
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
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PubMed Central
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7 April 2017
C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
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PubMed Central
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7 April 2017
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
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7 April 2017
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase
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PubMed Central
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7 April 2017
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution
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7 April 2017
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates
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7 April 2017
Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*
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7 April 2017
Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts
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27 September 2017
Unlimited multistability in multisite phosphorylation systems
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27 September 2017
Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion
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27 September 2017
Characterization of centrosomal localization and dynamics of Cdc25C phosphatase in mitosis.
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27 September 2017
Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.
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27 September 2017
Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses
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27 September 2017
Substrate competition as a source of ultrasensitivity in the inactivation of Wee1.
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27 September 2017
Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition
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27 September 2017
Multisite M-phase phosphorylation of Xenopus Wee1A
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27 September 2017
Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations
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27 September 2017
Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible
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Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2.
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27 September 2017
Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.
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27 September 2017
Regulation of Xenopus Cdc25 protein
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27 September 2017
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis
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27 September 2017
Theoretical dynamics of the cyclin B-MPF system: a possible role for p13suc1.
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27 September 2017
Cell cycle regulation of a Xenopus Wee1-like kinase
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27 September 2017
Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase
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27 September 2017
Cell cycle extracts
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27 September 2017
p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast
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27 September 2017
Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity
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27 September 2017
Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts
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30 May 2018
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation
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30 May 2018
Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase
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PubMed Central
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30 May 2018
A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1.
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30 May 2018
Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14.
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PubMed Central
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30 May 2018
Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos.
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30 May 2018
Cyclin activation of p34cdc2.
1 reference
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PubMed Central
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30 May 2018
Regulation of the cdc25 protein during the cell cycle in Xenopus extracts
1 reference
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PubMed Central
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30 May 2018
Pin1 acts catalytically to promote a conformational change in Cdc25.
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PubMed Central
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28 November 2018
Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
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28 November 2018
Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts
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28 November 2018
A model for a bistable biochemical trigger of mitosis
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28 November 2018
Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.
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28 November 2018
Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins
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Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast
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Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase
1 reference
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based on heuristic
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Identifiers
DOI
10.1016/J.MOLCEL.2011.01.012
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PMC publication ID
3060667
0 references
PubMed publication ID
21292159
0 references
ResearchGate publication ID
49808655
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