(Q24645334)

English

Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

0 references

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

author name string

Amanda Jones

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Jiyun Chen

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Dong Jin Hwang

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Duane D Miller

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

language of work or name

0 references

publication date

4 September 2008

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

150

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

385-395

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

7 April 2017

Discovery and therapeutic promise of selective androgen receptor modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

7 April 2017

Restoration of spermatogenesis by exogenously administered testosterone in rats made azoospermic by hypophysectomy or withdrawal of luteinizing hormone alone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

7 April 2017

Contraceptive efficacy of testosterone-induced azoospermia in normal men. World Health Organization Task Force on methods for the regulation of male fertility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

7 April 2017

Synergistic interaction of testosterone and oestradiol inhibits spermatogenesis in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

7 April 2017

A selective androgen receptor modulator for hormonal male contraception

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

7 April 2017

An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Drug insight: Recent advances in male hormonal contraception.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Of mice and men: the evolving phenotype of aromatase deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

In vitro and in vivo structure-activity relationships of novel androgen receptor ligands with multiple substituents in the B-ring

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Progress towards hormonal male contraception

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Pharmacodynamics of selective androgen receptor modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

A multicenter contraceptive efficacy study of injectable testosterone undecanoate in healthy Chinese men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Discovery of nonsteroidal androgens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Effect of testosterone and estradiol in a man with aromatase deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

27 September 2017

Effect of testosterone enanthate on testis size

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

30 May 2018

The effect of synthetic estrogen upon the biosynthesis in vitro of androgen and luteinizing hormone in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

30 May 2018

Effect of oestradiol benzoate on pituitary and testis function in the normal adult male rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

30 May 2018

Quantitative restoration of advanced spermatogenic cells in adult male rats made azoospermic by active immunization against luteinizing hormone or gonadotropin-releasing hormone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

30 May 2018

The androgen microenvironment of the human testis and hormonal control of spermatogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

28 November 2018

Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

28 November 2018

Characterization of normal spermiation and spermiation failure induced by hormone suppression in adult rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

28 November 2018

Impact of estrogen replacement therapy in a male with congenital aromatase deficiency caused by a novel mutation in the CYP19 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

28 November 2018

Effects of anabolic-androgenic steroid use or gonadal testosterone suppression on serum leptin concentration in men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

28 November 2018

Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630904

28 November 2018

The comparative actions of testosterone propionate and 5 -androstan-17 -ol-3-one propionate on the reproductive behaviour, physiology and morphology of male rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biphasic effect of testosterone on spermatogenesis in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Facilitation of mounting behavior by dihydrotestosterone propionate in castrated estradiol benzoate-treated male rats following pudendectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the androgen microenvironment of maturing spermatozoa

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maintenance of advanced spermatogenic cells in the adult rat testis: quantitative relationship to testosterone concentration within the testis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenously administered testosterone maintains spermatogenesis quantitatively in adult rats actively immunized against gonadotropin-releasing hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Follicle-stimulating hormone is required for the initial phase of spermatogenic restoration in adult rats following gonadotropin suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of serum leptin levels by gonadal function in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A detailed study on the role of sex steroid milieu in determining plasma leptin concentrations in adult male and female rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of androgen on spermatogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of oestrogen in male sexual behaviour: insights from the natural model of aromatase deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oestradiol enhances testosterone-induced suppression of human spermatogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spermiation failure is a major contributor to early spermatogenic suppression caused by hormone withdrawal in adult rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Male contraception

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure of 5α-Dihydrotestosterone to initiate Sexual Behaviour in the Castrated Male Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copulation in Castrated Male Rats following Combined Treatment with Estradiol and Dihydrotestosterone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contraceptive efficacy of testosterone-induced azoospermia in normal men

1 reference

https://api.crossref.org/works/10.1210%2FEN.2008-0674

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1210/EN.2008-0674

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18772237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

ResearchGate publication ID

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