(Q24646237)

English

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

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scholarly article

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NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas (English)

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author name string

Ta-Jen Liu

1

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Dimpy Koul

2

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Tiffany LaFortune

3

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Ningyi Tiao

4

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Rui Jun Shen

5

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Sauveur-Michel Maira

6

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Carlos Garcia-Echevrria

7

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W K Alfred Yung

8

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language of work or name

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publication date

August 2009

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Molecular Cancer Therapeutics

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8

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8

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2204-10

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The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

1 reference

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7 April 2017

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

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Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

1 reference

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

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Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

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7 April 2017

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752877

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The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

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Autophagy and cell death.

1 reference

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1 reference

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1 reference

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Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.

1 reference

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Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.

1 reference

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Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

1 reference

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Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis

1 reference

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Tumor angiogenesis in stage IB cervical cancer: correlation of microvessel density with survival

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1 reference

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Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

1 reference

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PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment

1 reference

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Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.

1 reference

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Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy.

1 reference

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PIK3CA gene mutations in pediatric and adult glioblastoma multiforme.

1 reference

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MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer

1 reference

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In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19671762

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy and cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19671762

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-09-0160

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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