(Q24648321)

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A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours

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scholarly article

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A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours (English)

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phase I clinical trial

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based on heuristic

inferred from title

colorectal carcinoma

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based on heuristic

inferred from title

Daniel Hochhauser

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ORCID Public Data File 2021

author name string

R J Francis

1

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S K Sharma

2

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C Springer

3

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A J Green

4

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L D Hope-Stone

5

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L Sena

6

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J Martin

7

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K L Adamson

8

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A Robbins

9

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L Gumbrell

10

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D O'Malley

11

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E Tsiompanou

12

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H Shahbakhti

13

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S Webley

14

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D Hochhauser

15

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A J Hilson

16

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D Blakey

17

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R H J Begent

18

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language of work or name

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publication date

9 September 2002

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British Journal of Cancer

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87

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600-7

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6

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Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

7 April 2017

Purification and Properties of Carboxypeptidase G1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

7 April 2017

Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

28 September 2017

Cyclosporine delays host immune response to antibody enzyme conjugate in ADEPT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

28 September 2017

The Functional Assessment of Cancer Therapy scale: development and validation of the general measure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

28 September 2017

Localisation of monoclonal antibodies reacting with different epitopes on carcinoembryonic antigen (CEA)--implications for targeted therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

28 September 2017

A phase-I study of repeated therapy with radiolabelled antibody to carcinoembryonic antigen using intermittent or continuous administration of cyclosporin A to suppress the immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

28 September 2017

Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

28 September 2017

A cytotoxic agent can be generated selectively at cancer sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

30 May 2018

Radioiodination for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

30 May 2018

Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

30 May 2018

Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6600517

21 January 2018

Metal ion-promoted binding of proteins to immobilized triazine dye affinity adsorbents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364249

28 November 2018

Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/12237768

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12237768

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of prodrug, active drug, and metabolites in an ADEPT clinical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12237768

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galactosylated antibodies and antibody-enzyme conjugates in antibody-directed enzyme prodrug therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12237768

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accurate quantification of 131I distribution by gamma camera imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/12237768

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6600517

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ResearchGate publication ID

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Springer Nature article ID

10.1038/sj.bjc.6600517

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