(Q24649967)

English

Biochemical Characterization of the Ran-RanBP1-RanGAP System: Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran-RanGAP GTPase Reaction?

scientific article published on November 1, 2003

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scholarly article

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Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction? (English)

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Biochemical Characterization of the Ran-RanBP1-RanGAP System: Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran-RanGAP GTPase Reaction? (English)

1 reference

10.1128/MCB.23.22.8124-8136.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8124-8136.2003

26 March 2024

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Alfred Wittinghofer

5

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author name string

Astrid Kraemer

2

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Marian Farkasovsky

3

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Carolin Körner

4

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Michael J. Seewald

1

0000-0001-6967-8993

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Europe PubMed Central

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Ingrid R. Vetter

6

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November 2003

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https://mcb.asm.org/content/23/22/8124.full.pdf

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https://europepmc.org/articles/PMC262373

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26 March 2024

https://doi.org/10.1128/mcb.23.22.8124-8136.2003

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https://journals.asm.org/doi/pdf/10.1128/MCB.23.22.8124-8136.2003

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10.1128/MCB.23.22.8124-8136.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8124-8136.2003

26 March 2024

https://www.tandfonline.com/doi/pdf/10.1128/MCB.23.22.8124-8136.2003

1 reference

10.1128/MCB.23.22.8124-8136.2003

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26 March 2024

Molecular and Cellular Biology

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23

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8124-36

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22

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SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles

1 reference

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A domain unique to plant RanGAP is responsible for its targeting to the plant nuclear rim

1 reference

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Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B

1 reference

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1 reference

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SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex

1 reference

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A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

1 reference

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7 April 2017

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

1 reference

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Identification of different roles for RanGDP and RanGTP in nuclear protein import

1 reference

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RanGAP1 induces GTPase activity of nuclear Ras-related Ran

1 reference

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7 April 2017

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1

1 reference

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7 April 2017

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport

1 reference

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A giant nucleopore protein that binds Ran/TC4

1 reference

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The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA

1 reference

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7 April 2017

The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus

1 reference

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7 April 2017

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

7 April 2017

Transport between the cell nucleus and the cytoplasm

1 reference

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7 April 2017

RanGAP mediates GTP hydrolysis without an arginine finger

1 reference

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7 April 2017

The crystal structure of rna1p: a new fold for a GTPase-activating protein

1 reference

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7 April 2017

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

1 reference

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7 April 2017

The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+

1 reference

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7 April 2017

Raster3D: photorealistic molecular graphics

1 reference

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7 April 2017

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

7 April 2017

Calculation of protein extinction coefficients from amino acid sequence data

1 reference

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7 April 2017

New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability.

1 reference

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7 April 2017

The acidic C-terminal domain of rna1p is required for the binding of Ran.GTP and for RanGAP activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

7 April 2017

Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C

1 reference

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7 April 2017

Nucleocytoplasmic transport: the soluble phase

1 reference

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7 April 2017

Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats

1 reference

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7 April 2017

Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

1 reference

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7 April 2017

RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

7 April 2017

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

1 reference

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7 April 2017

Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae

1 reference

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7 April 2017

Macromolecule Synthesis in Temperature-sensitive Mutants of Yeast

1 reference

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7 April 2017

Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation

1 reference

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28 September 2017

The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

28 September 2017

The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly

1 reference

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28 September 2017

The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import

1 reference

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28 September 2017

Plant RanGAPs are localized at the nuclear envelope in interphase and associated with microtubules in mitotic cells

1 reference

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28 September 2017

The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion

1 reference

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28 September 2017

Kinetic studies of protein-protein interactions

1 reference

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28 September 2017

Systems analysis of Ran transport

1 reference

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28 September 2017

Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time

1 reference

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28 September 2017

Kinetic analysis of translocation through nuclear pore complexes

1 reference

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28 September 2017

Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

28 September 2017

The fission yeast ran GTPase is required for microtubule integrity

1 reference

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28 September 2017

Electrostatic aspects of protein-protein interactions.

1 reference

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28 September 2017

The direction of transport through the nuclear pore can be inverted

1 reference

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28 September 2017

RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import

1 reference

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Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences

1 reference

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28 September 2017

A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

28 September 2017

The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

28 September 2017

Structural and functional analyses of Saccharomyces cerevisiae wild-type and mutant RNA1 genes

1 reference

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1 reference

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A yeast mutant which accumulates precursor tRNAs

1 reference

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28 September 2017

Disassembly of RanGTP-karyopherin beta complex, an intermediate in nuclear protein import.

1 reference

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1 reference

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1 reference

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GTP hydrolysis is required for vesicle fusion during nuclear envelope assembly in vitro

1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

28 November 2018

GTP hydrolysis by Ran is required for nuclear envelope assembly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

28 November 2018

Aluminum fluoride associates with the small guanine nucleotide binding proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

28 November 2018

Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

28 November 2018

Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=262373

28 November 2018

The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran GTPase-activating protein (RanGAP) inhibition by karyopherin beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid, electrostatically assisted association of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different Structural and Kinetic Requirements for the Interaction of Ran with the Ran-Binding Domains from RanBP2 and Importin-β

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex†

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Individual Rate Constants for the Interaction of Ras Proteins with GTPase-Activating Proteins Determined by Fluorescence Spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The conserved arginine in rho-GTPase-activating protein is essential for efficient catalysis but not for complex formation with Rho.GDP and aluminum fluoride

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14585972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1128%2FMCB.23.22.8124-8136.2003

7 January 2021

based on heuristic

inferred from DOI database lookup

The Crystal Structure of rna1p

1 reference

https://api.crossref.org/works/10.1128%2FMCB.23.22.8124-8136.2003

7 January 2021

based on heuristic

inferred from DOI database lookup

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1128%2FMCB.23.22.8124-8136.2003

7 January 2021

based on heuristic

inferred from DOI database lookup

Technical tips online

1

1

P01525

author name string

Agatep R.

publication date

1998

1 reference

10.1128/MCB.23.22.8124-8136.2003

https://api.crossref.org/works/10.1128/MCB.23.22.8124-8136.2003

26 March 2024

Identifiers

10.1128/MCB.23.22.8124-8136.2003

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