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PCAF acetylates {beta}-catenin and improves its stability
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title
PCAF acetylates {beta}-catenin and improves its stability
(English)
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main subject
cell biology
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author name string
Xinjian Ge
series ordinal
1
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Qihuang Jin
series ordinal
2
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Fang Zhang
series ordinal
3
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Tingting Yan
series ordinal
4
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Qiwei Zhai
series ordinal
5
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language of work or name
English
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publication date
January 2009
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published in
Molecular Biology of the Cell
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volume
20
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issue
1
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page(s)
419-27
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cites work
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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
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The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60
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Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
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The PCAF acetylase complex as a potential tumor suppressor
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Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction
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The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression
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Wnt signalling in stem cells and cancer
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beta-catenin is a target for the ubiquitin-proteasome pathway
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Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation
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Wnt signaling: is the party in the nucleus?
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Beta-catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells
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28 September 2017
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity
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28 September 2017
Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells
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28 September 2017
beta-catenin-mediated signaling: a molecular target for early chemopreventive intervention
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28 September 2017
Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics
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28 September 2017
Wnt breakers in colon cancer
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28 September 2017
A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability
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28 September 2017
PCAF is a coactivator for p73-mediated transactivation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1.
1 reference
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PubMed Central
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28 September 2017
Lentiviral-mediated RNA interference
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28 September 2017
Acetylation of beta-catenin by CREB-binding protein (CBP).
1 reference
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PubMed Central
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28 September 2017
Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
Regulation of beta -catenin transformation by the p300 transcriptional coactivator.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
Regulation of E2F1 activity by acetylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
Cytoskeletal reorganization by soluble Wnt-3a protein signalling
1 reference
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PubMed Central
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28 September 2017
The histone acetylase PCAF is a nuclear receptor coactivator.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
p300 gene alterations in colorectal and gastric carcinomas.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 September 2017
Targeting the active beta-catenin pathway to treat cancer cells.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 November 2018
Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 November 2018
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613091
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28 November 2018
Identifiers
DOI
10.1091/MBC.E08-08-0792
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4315227
OpenCitations bibliographic resource ID
4315227
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4315227
PMCID
2613091
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4315227
PubMed ID
18987336
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4315227
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